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Common west African HLA antigens are associated with protection from severe malaria.
A V Hill
1 ,
C E Allsopp ,
D Kwiatkowski ,
N M Anstey ,
P Twumasi ,
P A Rowe ,
S Bennett ,
D Brewster ,
A J McMichael ,
B M Greenwood
Aug 15 1991
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Abstract
A large case-control study of malaria in West African children shows that a human leucocyte class I antigen (HLA-Bw53) and an HLA class II haplotype (DRB1*1302-DQB1*0501), common in West Africans but rare in other racial groups, are independently associated with protection from severe malaria. In this population they account for as great a reduction in disease incidence as the sickle-cell haemoglobin variant. These data support the hypothesis that the extraordinary polymorphism of major histocompatibility complex genes has evolved primarily through natural selection by infectious pathogens.