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Spliceosomal UsnRNP biogenesis, structure and function
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Abstract
Significant advances have been made in elucidating the biogenesis pathway and three-dimensional
structure of the UsnRNPs, the building blocks of the spliceosome. U2 and U4/U6*U5
tri-snRNPs functionally associate with the pre-mRNA at an earlier stage of spliceosome
assembly than previously thought, and additional evidence supporting UsnRNA-mediated
catalysis of pre-mRNA splicing has been presented.