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      Higher 17α-Hydroxyprogesterone Levels Aggravated the Severity of Male Adolescent Acne in Northeast China

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          Abstract

          Background: The relationship between serum hormone levels and adolescent acne is not fully clarified. Objective: To determine the relationship between levels of androstenedione, dehydroepiandrosterone sulfate (DHEA-S), testosterone, estradiol and 17α-hydroxyprogesterone (17-OHP) with adolescent acne in Northeast China. Methods: A transversal study included 242 acne cases and 188 controls. All data were analyzed using SPSS version 17.0. Results: Androstenedione and testosterone levels were significantly higher (p < 0.0001) in the cases than in the control group. In males, the difference in 17-OHP levels was statistically significant (p < 0.0001), as well as between mild and severe acne cases (p = 0.002). The estradiol level was significantly different (p < 0.0001) between cases and controls in females. Conclusion: Higher androstenedione and testosterone levels are significant risk factors in the occurrence of adolescent acne. A higher 17-OHP level aggravates the severity of male adolescent acne, while a higher estradiol level protects females against the onset of adolescent acne.

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          Role of hormones in acne vulgaris.

          Vineet M Arora, Amita Yadav, Vandana Saini (2011)
          To elucidate the role of endogenous hormones like testosterone, progesterone, estrogen, insulin-like growth factor, insulin and glucocorticoids in a common skin condition acne vulgaris. We conducted a systematic review of the literature and abstracted the data for every published cut point. We screened more than 1000 studies and found that serum testosterone, progesterone, glucocorticoids, insulin and insulin-like growth factors are increased in patients with acne vulgaris and serum estrogen levels are low in patients. Various endogenous hormones play important role in the pathogenesis of acne vulgaris. Thus, in the clinical practice it is important to evaluate serum levels of these hormones and patients must be treated accordingly to avoid serious endocrine disorders at an early age. Copyright © 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
          Article 0 comments Cited 31 times – based on 0 reviews     Review now
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            The epidemiology of adolescent acne in North East China.

            Ting T. Xiao, Kevin Wei, H. Chen … (2010)
            Adolescent acne impacts self-esteem and quality of life in adolescents and its aetiology is not fully clarified. The aim of this study was to describe the epidemiological features of adolescent acne in North East China and determine the impact of genetic and environmental factors on the pathogenesis of acne. Data were collected from 5696 undergraduates (2920 patients and 2776 controls) using questionnaire. The survey data were analysed using spss version 13.0 and heritability of adolescent acne was calculated using Falconer's method. Total prevalence of adolescent acne was 51.30% (52.74% in males, 49.65% in females). The difference between genders was statistically significant (P < 0.05). Adolescents with a family history of acne had earlier age of onset (P < 0.001). The prevalence of acne in first- and second-degree relatives of acne patients was 22.5% and 7.19%, respectively, significantly higher than in controls (P < 0.001). Heritability of adolescent acne was 78.47 +/- 2.05% in first-degree relatives and 75.05 +/- 3.18% in second-degree relatives. Risk factors to the acne suffers include (in descending order of occurrence), acne family history, mental stress, menstrual disorder, frequent insomnia, high fat diet, being male, dysmenorrhoea, anxiety, sleeping < 8 h per day, depression, fried food, study pressure, spicy food, oily skin and mixed type skin. Protective factors include (presented in descending order of occurrence) dry skin, neutral skin, frequent fruit consumption and computer access time < 2 h daily. Adolescent acne includes a familial genetic predisposition. Additional environmental factors of psychological stress, skin oiliness and high caloric diets may also contribute to the onset of acne in Chinese adolescents.
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              Acne in schoolchildren: no longer a concern for dermatologists.

              J Garioch, Kit N Simpson, Carin M. A. Rademaker (1989)
              To determine the prevalence and severity of acne among schoolchildren in Glasgow. Secondary schools in Glasgow were divided by postcode into five socioeconomic cluster groups. Different numbers of schools were selected at random from the five groups to ensure proportional representation. One class from each registration year of the chosen schools was selected at random and the whole class recruited into the study. 15 Secondary schools in Glasgow. 2014 Randomly selected schoolchildren aged 12-17 (5% of total secondary school roll). None. Assessment of facial acne by two independent examiners by a recognised acne scoring system. The prevalence of acne in boys increased from 40% (75/189) at age 12 to 95% (108/114) at age 16, and in girls it increased from 61% (114/187) at age 12 to 83% (136/164) at age 16. On a scale of 0 to 10 only 18 boys (1.8%) and three girls (0.3%) had grades of acne of 1.0 or greater; most of the pupils had grade 0.05-0.375 (minimal) acne. Nine per cent of boys (88/973) and 14% of girls (145/1041) had visited their general practitioner specifically for advice on and treatment for acne; only five pupils (0.3%) had been referred to a dermatologist. Both the prevalence and severity of acne have decreased over the past 20 years. This has probably been due to improvement of treatment for acne by primary care doctors and the greater availability and use of over the counter preparations for acne.
              Article 0 comments Cited 27 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (publisher-id): DRM
                Journal ID (nlm-ta): Dermatology
                Journal ID (doi): 10.1159/issn.1018-8665
                Title: Dermatology
                Publisher: S. Karger AG
                ISSN (Print): 1018-8665
                ISSN (Electronic): 1421-9832
                Publication date Subscription-year: 2014
                Publication date (Print): December 2014
                Publication date (Electronic): 19 November 2014
                Volume: 229
                Issue: 4
                Pages: 359-362
                Affiliations
                aDepartment of Dermatology, 1st Hospital of Chongqing Medical University, Chongqing, and bDepartment of Dermatology, No. 1 Hospital of China Medical University, Shenyang, China; cDepartment of Dermatology, Mount Sinai Medical Center, New York, N.Y., USA
                Author notes
                *Dr. Chundi He, Department of Dermatology, No. 1 Hospital of China Medical University, 155 N. Nanjing Street, Shenyang 110001 (China), E-Mail chundihe@hotmail.com
                Article
                Publisher ID: 365656 Other ID: Dermatology 2014;229:359-362
                DOI: 10.1159/000365656
                PubMed ID: 25413081
                SO-VID: 470ea0cd-def0-43d4-aac0-c021915d180c
                Copyright © © 2014 S. Karger AG, Basel
                License:

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                History
                Date received : 25 March 2014
                Date accepted : 30 June 2014
                Page count
                Tables: 2, Pages: 4
                Categories
                Subject: Original Paper

                ScienceOpen disciplines: Oncology & Radiotherapy,Pathology,Surgery,Dermatology,Pharmacology & Pharmaceutical medicine
                Keywords: 17α-Hydroxyprogesterone,Adolescent acne,Estradiol,Testosterone,Androstenedione,Dehydroepiandrosterone sulfate
                Data availability:
                ScienceOpen disciplines: Oncology & Radiotherapy, Pathology, Surgery, Dermatology, Pharmacology & Pharmaceutical medicine
                Keywords: 17α-Hydroxyprogesterone, Adolescent acne, Estradiol, Testosterone, Androstenedione, Dehydroepiandrosterone sulfate

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