The apatinib inhibits breast cancer cell line MDA-MB-231 in vitro by inducing apoptosis, cell cycle arrest, and regulating nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways.

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Abstract

Breast cancer is one of the most common cancers and leading causes of death in the women worldwide. The evidence shows efficacy of apatinib against breast cancer. Accordingly, the present study was conducted to investigate the effect of apatinib on apoptosis, cell cycle, and Mitogen‑Activated Protein Kinase (MAPK) and nuclear factor-κB (NF-κB) signaling pathways in the breast cancer MDA-MB-231 cell line.

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Author and article information

Journal

Journal ID (iso-abbrev): Breast Cancer

Title: Breast cancer (Tokyo, Japan)

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1880-4233

ISSN (Print): 1340-6868

Publication date (Electronic): Jul 2020

Volume: 27

Issue: 4

Affiliations

[1 ] Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

[2 ] Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

[3 ] Department of Medical Laboratory Sciences, Faculty of Medicine, Islamic Azad University (IAU), Sari, Iran.

[4 ] Clinical Laboratory Medicine Department, Rofeydeh Hospital, University of Social Welfare and Rehabilition Sciences (USWR), Tehran, Iran.

[5 ] Department of Biochemistry, Erasmus University Medical Center, Rotterdam, The Netherlands.

[6 ] Department of Biochemistry, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.

[7 ] Bioinformatics and Computational Biology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

[8 ] Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

[9 ] Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

[10 ] Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.

[11 ] Stem Cell And Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran. Rashidi@tbzmed.ac.ir.

[12 ] Stem Cell And Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran. nourimd@yahoo.com.

Article

Publisher Item ID: 10.1007/s12282-020-01055-6

DOI: 10.1007/s12282-020-01055-6

PubMed ID: 32026267

SO-VID: 4720fd6f-df96-4048-82d3-430aef70abce

History

Keywords: MAPK,Breast cancer,Nf-κb,Apatinib

Data availability:

Keywords: MAPK, Breast cancer, Nf-κb, Apatinib

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