Prospective neonatal screening for severe T- and B-lymphocyte deficiencies in Seville.

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Abstract

Early diagnosis of primary immunodeficiency such as severe combined immunodeficiency (SCID) and X-linked agammaglobulinemia (XLA) improves outcome of affected children. T-cell-receptor-excision circles (TRECs) and kappa-deleting-recombination-excision circles (KRECs) determination from dried blood spots (DBS) identify neonates with severe T- and/or B-lymphopenia. No prospective data exist of the impact of gestational age (GA) and birth weight (BW) on TRECs and KRECs values.

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Author and article information

Journal

Journal ID (iso-abbrev): Pediatr Allergy Immunol

Title: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

Publisher: Wiley-Blackwell

ISSN (Electronic): 1399-3038

ISSN (Print): 0905-6157

Publication date (Electronic): Feb 2016

Volume: 27

Issue: 1

Affiliations

[1 ] Seccion de Infectología e Inmunodeficiencias, Unidad de Pediatria, Hospital Virgen del Rocío, Sevilla/Instituto de Biomedicina de Sevilla (IBiS), Sevilla, Spain.

[2 ] Unidad de Inmunología, Hospital Universitario Virgen del Rocío, Sevilla, Spain.

[3 ] Unidad de Metabolopatías, Hospital Universitario Virgen del Rocío, Sevilla, Spain.

[4 ] Unidad de Neonatología, Hospital Universitario Virgen del Rocío, Sevilla, Spain.

[5 ] Unidad de Pediatría, Hospital Virgen de Valme, Sevilla, Spain.

[6 ] Unidad de Neonatología, Hospital Universitario Virgen de Macarena, Sevilla, Spain.

[7 ] Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Institut de Recerca Vall d'Hebron, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.

[8 ] Division of Immune Deficiency, Department of Pediatrics, Hospital 12 de Octubre, Madrid, Spain.

[9 ] Unidad de Enfermedades Infecciosas e Inmunodeficiencias, UGP de Pediatría. Hospital Materno-Infantil, Hospital Regional Universitario de Málaga, Málaga, Spain.

[10 ] Division of Clinical Immunology and Transfusion Medicine, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.

[11 ] Translational Centre for Regenerative Medicine (TRM), University of Leipzig, Leipzig, Germany.

[12 ] ImmunoDeficiencyCenter Leipzig at Hospital St Georg gGmbH Leipzig, Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, Leipzig, Germany.

Article

DOI: 10.1111/pai.12501

PubMed ID: 26498110

SO-VID: 48444112-bbb5-440c-bd4f-43848b5b5f58

History

Keywords: KRECS,New born screening,TRECS,severe lymphopenias

Data availability:

Keywords: KRECS, New born screening, TRECS, severe lymphopenias

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