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Marked stimulation of glucagon release and modest stimulation of insulin release were
observed during in situ perfusion of the rat pancreas with AVP or OT. Glucagon release
in response to AVP or OT (200 pg/ml) gradually increased over a 45 min perfusion period
reaching maxima of 500% and 300% of the pre-stimulatory levels, respectively. Insulin
release transiently increased by 100%. In each case release rates returned to control
values immediately after withdrawal of the peptides. Total glucagon release was concentration
dependent and linear from 20 pg to 20 ng AVP or OT/ml (r greater than .97). Pancreatic
response to DDAVP perfused at 20 ng/ml was virtually indistinguishable from that induced
by AVP at 200 pg/ml. This demonstration of a glucagonotrophic action of the neurohypophysial
hormones in the in situ perfused rat pancreas confirms earlier studies using isolated
islets and bolus IV injection.