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      JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes.

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      Publication date:
      Journal: Nature immunology
      Keywords: Animals, Antigens, CD18, metabolism, Binding Sites, CHO Cells, Cell Adhesion, Cell Adhesion Molecules, Chemokine CXCL12, Chemokines, CXC, pharmacology, Chemotaxis, Leukocyte, immunology, Cricetinae, Endothelium, Vascular, Humans, Immunologic Memory, Jurkat Cells, Ligands, Lymphocyte Function-Associated Antigen-1, Membrane Proteins, antagonists & inhibitors, Neutrophils, Protein Binding, Receptors, Cell Surface, T-Lymphocytes, Tetradecanoylphorbol Acetate

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          Abstract

          Inflammatory recruitment of leukocytes is governed by dynamic interactions between integrins and endothelial immunoglobulin superfamily (IgSF) proteins. We have identified the IgSF member junctional adhesion molecule 1 (JAM-1) as a ligand of the beta(2) integrin lymphocyte function-associated antigen 1 (LFA-1). Under static and physiological flow conditions, JAM-1 contributed to LFA-1-dependent transendothelial migration of T cells and neutrophils as well as LFA-1-mediated arrest of T cells. The latter was triggered by chemokines on endothelium that was stimulated with cytokines to redistribute JAM-1 from the tight junctions. Transfectants expressing JAM-1 supported LFA-1-mediated adhesion of leukocytes, which required the membrane-proximal Ig-like domain 2 of JAM-1. Thus, JAM-1 is a counter-receptor for LFA-1 that is ideally situated to guide and control transmigration during leukocyte recruitment.

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          PubMed ID:: 11812992
          DOI:: 10.1038/ni755

          ScienceOpen disciplines: Chemistry
          Keywords: Animals,Antigens, CD18,metabolism,Binding Sites,CHO Cells,Cell Adhesion,Cell Adhesion Molecules,Chemokine CXCL12,Chemokines, CXC,pharmacology,Chemotaxis, Leukocyte,immunology,Cricetinae,Endothelium, Vascular,Humans,Immunologic Memory,Jurkat Cells,Ligands,Lymphocyte Function-Associated Antigen-1,Membrane Proteins,antagonists & inhibitors,Neutrophils,Protein Binding,Receptors, Cell Surface,T-Lymphocytes,Tetradecanoylphorbol Acetate
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          ScienceOpen disciplines: Chemistry
          Keywords: Animals, Antigens, CD18, metabolism, Binding Sites, CHO Cells, Cell Adhesion, Cell Adhesion Molecules, Chemokine CXCL12, Chemokines, CXC, pharmacology, Chemotaxis, Leukocyte, immunology, Cricetinae, Endothelium, Vascular, Humans, Immunologic Memory, Jurkat Cells, Ligands, Lymphocyte Function-Associated Antigen-1, Membrane Proteins, antagonists & inhibitors, Neutrophils, Protein Binding, Receptors, Cell Surface, T-Lymphocytes, Tetradecanoylphorbol Acetate

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