For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
4
views
31
references
 Top references
cited by
17
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      86
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Natural Deep Eutectic Solvents for the Extraction of Bioactive Steroidal Saponins from Dioscoreae Nipponicae Rhizoma

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          In the present study, a simple and environmentally friendly extraction method based on natural deep eutectic solvents (NADESs) was established to extract four bioactive steroidal saponins from Dioscoreae Nipponicae Rhizoma (DNR). A total of twenty-one types of choline chloride, betaine, and L-proline based NADESs were tailored, and the NADES composed of 1:1 molar ratio of choline chloride and malonic acid showed the best extraction efficiency for the four steroidal saponins compared with other NADESs. Then, the extraction parameters for extraction of steroidal saponins by selected tailor-made NADES were optimized using response surface methodology and the optimal extraction conditions are extraction time, 23.5 min; liquid–solid ratio, 57.5 mL/g; and water content, 54%. The microstructure of the DNR powder before and after ultrasonic extraction by conventional solvents (water and methanol) and the selected NADES were observed using field emission scanning electron microscope. In addition, the four steroidal saponins were recovered from NADESs by D101 macroporous resin with a satisfactory recovery yield between 67.27% and 79.90%. The present research demonstrates that NADESs are a suitable green media for the extraction of the bioactive steroidal saponins from DNR, and have a great potential as possible alternatives to organic solvents for efficiently extracting bioactive compounds from natural products.

          Related collections

          Most cited references31

          • Record: found
          • Abstract: found
          • Article: not found

          Response surface methodology (RSM) as a tool for optimization in analytical chemistry.

          Marcos Almeida Bezerra, Ricardo Santelli, Eliane Oliveira … (2008)
          A review about the application of response surface methodology (RSM) in the optimization of analytical methods is presented. The theoretical principles of RSM and steps for its application are described to introduce readers to this multivariate statistical technique. Symmetrical experimental designs (three-level factorial, Box-Behnken, central composite, and Doehlert designs) are compared in terms of characteristics and efficiency. Furthermore, recent references of their uses in analytical chemistry are presented. Multiple response optimization applying desirability functions in RSM and the use of artificial neural networks for modeling are also discussed.
          Article 0 comments Cited 434 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Tailoring properties of natural deep eutectic solvents with water to facilitate their applications.

            Young Choi, Yuntao Dai, Geert-Jan Witkamp … (2015)
            Previously it was demonstrated that natural deep eutectic solvents (NADES) are promising green solvents for the extraction of natural products. However, despite their potential, an obvious disadvantage of NADES is the high viscosity. Here we explored the dilution effect on the structures and physicochemical properties of NADES and their improvements of applications using quercetin and carthamin. The results of FT-IR and (1)H NMR experiments demonstrated that there are intensive H-bonding interactions between the two components of NADES and dilution with water caused the interactions weaken gradually and even disappeared completely at around 50% (v/v) water addition. A small amount of water could reduce the viscosity of NADES to the range of water and increase the conductivity by up to 100 times for some NADES. This study provides the basis for modulating NADES in a controllable way for their applications in food processing, enzyme reactions, pharmaceuticals and cosmetics.
            Article 0 comments Cited 263 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Natural Deep Eutectic Solvents: Properties, Applications, and Perspectives

              J. Friesen, Shao-Nong Chen, Guido Pauli … (2017)
              As functional liquid media, natural deep eutectic solvent (NADES) species can dissolve natural or synthetic chemicals of low water solubility. Moreover, the special properties of NADES, such as biodegradability and biocompatibility, suggest that they are alternative candidates for concepts and applications involving some organic solvents and ionic liquids. Owing to the growing comprehension of the eutectic mechanisms and the advancing interest in the natural eutectic phenomenon, many NADES applications have been developed in the past several years. However, unlike organic solvents, the basic structural unit of NADES media primarily depends on the intermolecular interactions among their components. This makes NADES matrices readily influenced by various factors, such as water content, temperature, and component ratio and, thus, extends the metabolomic challenge of natural products (NPs). To enhance the understanding of the importance of NADES in biological systems, this review focuses on NADES properties and applications in NP research. The present thorough chronological and statistical analysis of existing report adds to the recognition of the distinctiveness of (NA)DES, involves a discussion of NADES-related observations in NP research, and reportes applications of these eutectic mixtures. The work identifies potential areas for future studies of (NA)DES by evaluating relevant applications, including their use as extraction and chromatographic media as well as their biomedical relevance. The chemical diversity of natural metabolites that generate or participate in NADES formation highlights the growing insight that biosynthetically primordial metabolites (PRIMs) are as essential to the biological function and bioactivity of unrefined natural products as the biosynthetically more highly evolutionary metabolites (HEVOs) that can be isolated from crude mixtures.
              Article 0 comments Cited 206 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Alexander Shikov: Role: Academic Editor
                Ivana Radojcic Redovnikovic: Role: Academic Editor
                Journal
                Journal ID (nlm-ta): Molecules
                Journal ID (iso-abbrev): Molecules
                Journal ID (publisher-id): molecules
                Title: Molecules
                Publisher: MDPI
                ISSN (Electronic): 1420-3049
                Publication date (Electronic): 05 April 2021
                Publication date Collection: April 2021
                Volume: 26
                Issue: 7
                Electronic Location Identifier: 2079
                Affiliations
                [1 ]Traditional Chinese Medicine Processing Technology Innovation Center of Hebei Province, Hebei University of Chinese Medicine, Shijiazhuang 050200, China; Yangguiya_310@ 123456163.com (G.-Y.Y.); junnassong@ 123456163.com (J.-N.S.); Czuoya_123@ 123456163.com (Y.-Q.C.); wanglei1031@ 123456126.com (L.W.); zyg314@ 123456163.com (Y.-G.Z.)
                [2 ]Hebei Chemical & Pharmaceutical College, Shijiazhuang 050200, China
                Author notes
                [* ]Correspondence: zhangdan@ 123456hebcm.edu.cn (D.Z.); guolong@ 123456hebcm.edu.cn (L.G.); Tel.: +86-0311-8992-6017 (D.Z. & L.G.)
                [†]

                These authors contributed equally to this work.

                Author information
                https://orcid.org/0000-0002-2571-5542
                Article
                Publisher ID: molecules-26-02079
                DOI: 10.3390/molecules26072079
                PMC ID: 8038615
                PubMed ID: 33916390
                SO-VID: 4adf5c81-d976-48ad-a7f4-8edc1c97bf0e
                Copyright © © 2021 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( https://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 03 March 2021
                Date accepted : 02 April 2021
                Categories
                Subject: Article

                Keywords: natural deep eutectic solvents,dioscoreae nipponicae rhizoma,steroidal saponins,response surface methodology,extraction
                Data availability:
                Keywords: natural deep eutectic solvents, dioscoreae nipponicae rhizoma, steroidal saponins, response surface methodology, extraction

                Comments

                Comment on this article

                scite_

                Similar content86

                See all similar

                Cited by17

                See all cited by

                Most referenced authors364

                See all reference authors