CD47 blockade reduces ischemia-reperfusion injury and improves outcomes in a rat kidney transplant model.

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Abstract

Ischemia-reperfusion injury (IRI) significantly contributes to delayed graft function and inflammation, leading to graft loss. Ischemia-reperfusion injury is exacerbated by the thrombospondin-1-CD47 system through inhibition of nitric oxide signaling. We postulate that CD47 blockade and prevention of nitric oxide inhibition reduce IRI in organ transplantation.

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Journal

Journal ID (iso-abbrev): Transplantation

Title: Transplantation

ISSN (Electronic): 1534-6080

ISSN (Print): 0041-1337

Publication date (Electronic): Aug 27 2014

Volume: 98

Issue: 4

Affiliations

[1 ] 1 Department of Surgery, Washington University School of Medicine, St. Louis, MO. 2 Vasculox, Inc., St. Louis, MO. 3 Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO. 4 Departments of Biochemistry and Molecular Biophysics, Cell Biology, and Physiology, Washington University School of Medicine, St. Louis, MO. 5 Address correspondence to: William C. Chapman, Washington University School of Medicine, 660 S. Euclid Ave., Campus Box 8109, St. Louis, MO 63110.

Article

Mid ID: NIHMS608935

DOI: 10.1097/TP.0000000000000252

PubMed ID: 24983310

SO-VID: 4b1be827-13fb-4ad5-9de1-ae16906168bb

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