Eisuke Mochizuki 1 , Yoshiihiro Kawai 2 , Keisuke Morikawa 1 , Yutaro Ito 1 , Namio Kagoo 1 , Tsutomu Kubota 1 , Koshiro Ichijyo 1 , Masahiro Uehara 1 , Masanori Harada 1 , Shun Matsuura 1 , Masaru Tsukui 1 , Naoki Koshimizu 1
20 November 2020
The validity of four-dimensional dynamic-ventilation CT scan for distinguishing COPD from asthma has not been established.
To assess whether four-dimensional dynamic-ventilation CT scan can aid in the diagnosis of COPD by comparing local lung movement during tidal breathing between COPD and asthma.
Thirty-three COPD patients (30 males and three females; median age 74; range 44–89 years) and 11 asthma patients (five males and six females; median age 55; range: 32–75 years) underwent whole-lung dynamic-ventilation CT scan. CT data were reconstructed, one respiratory cycle to 10 phases, and in addtion we reconstructed threefold new phase data sets. We then analyzed local lung movement during tidal breathing using unpaired t-tests and chi-squared tests.
The local lung movement in COPD patients was significantly smaller than in asthma patients, especially in the ventral part of the lung. This was so even in patients who had mild emphysema (Goddard score <8).