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Deep Sequencing Analysis Reveals That KRAS Mutation Is a Marker of Poor Prognosis in Patients with Pulmonary Sarcomatoid Carcinoma
Filippo Lococo ,
Greta Gandolfi ,
Giulio Rossi ,
Carmine Pinto ,
Cristian Rapicetta ,
Alberto Cavazza ,
Alfredo Cesario ,
Carla Galeone ,
Massimiliano Paci ,
Alessia Ciarrocchi
August 2016
August 2016
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Abstract
Pulmonary sarcomatoid carcinoma (PSC) is a rare and aggressive subset of non-small
cell lung cancer with limited treatment options. The molecular characterization of
PSC has been strongly hampered by the relative rarity of these tumors. However, understanding
the molecular and genetic bases of PSCs is critical to pave the way to new treatment
options. In this work, we aimed to explore the complexity of the genetic asset of
PSC and investigate its prognostic impact on survival in a large cohort of patients
with PSC.