Paula F. Zamora:
ORCID: https://orcid.org/0000-0002-5246-4718
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: SupervisionRole: ValidationRole: VisualizationRole:
Writing – original draftRole: Writing – review & editing
Thomas G. Reidy: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Writing – review & editing
Catherine R. Armbruster: Role: Formal analysisRole: Funding acquisitionRole: InvestigationRole: MethodologyRole:
VisualizationRole: Writing – review & editing
Ming Sun: Role: InvestigationRole: Methodology
Daria Van Tyne: Role: MethodologyRole: ResourcesRole: Writing – review & editing
Paul E. Turner: Role: MethodologyRole: ResourcesRole: Writing – review & editing
Jonathan L. Koff: Role: MethodologyRole: SupervisionRole: Writing – review & editing
Jennifer M. Bomberger:
ORCID: https://orcid.org/0000-0003-4767-6238
Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: MethodologyRole:
SupervisionRole: VisualizationRole: Writing – original draftRole: Writing – review
& editing
Jeremy Barr: Role: Editor
Journal ID (nlm-ta): PLoS Biol
Journal ID (iso-abbrev): PLoS Biol
Journal ID (publisher-id): plos
Title:
PLOS Biology
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1544-9173
ISSN
(Electronic):
1545-7885
Publication date
(Electronic):
23
April
2024
Publication date Collection:
April
2024
Publication date PMC-release: 23
April
2024
Volume: 22
Issue: 4
Electronic Location Identifier: e3002566
Affiliations
[1
]
Department of Microbiology and Immunology, Dartmouth Geisel School of Medicine, Hanover,
New Hampshire, United States of America
[2
]
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania,
United States of America
[3
]
Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania,
United States of America
[4
]
Center for Biological Imaging, University of Pittsburgh, Pittsburgh, Pennsylvania,
United States of America
[5
]
Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania,
United States of America
[6
]
Center for Phage Biology and Therapy, Yale University, New Haven, Connecticut, United
States of America
[7
]
Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut,
United States of America
[8
]
Program in Microbiology, Yale School of Medicine, New Haven, Connecticut, United States
of America
[9
]
Quantitative Biology Institute, Yale University, New Haven, Connecticut, United States
of America
[10
]
Department of Medicine, Yale University, New Haven, Connecticut, United States of
America
Monash University, AUSTRALIA
Author notes
PET is cofounder of Felix Biotechnology, Inc., a company that seeks to develop phages
for human therapy. Yale University has an institutional conflict of interest related
to this project (PET & JLK). Yale may receive financial benefit related to the therapy
used in this protocol.
Author information
Article
Publisher ID:
PBIOLOGY-D-23-02532
DOI: 10.1371/journal.pbio.3002566
PMC ID: 11037538
PubMed ID: 38652717
SO-VID: 4eb182c7-3380-4bc5-9990-1f93c22c0fa4
Copyright © © 2024 Zamora et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by:
funder-id http://dx.doi.org/10.13039/100000897, Cystic Fibrosis Foundation;
Award ID: ZAMORA20F0
Award Recipient
:
ORCID: https://orcid.org/0000-0002-5246-4718
Paula F. Zamora
Funded by:
funder-id http://dx.doi.org/10.13039/100000060, National Institute of Allergy and Infectious Diseases;
Award ID: T32AI060525
Award Recipient
:
ORCID: https://orcid.org/0000-0002-5246-4718
Paula F. Zamora
Funded by:
funder-id http://dx.doi.org/10.13039/100000897, Cystic Fibrosis Foundation;
Award ID: ARMBRU19F0
Award Recipient
:
Catherine R. Armbruster
Funded by:
funder-id http://dx.doi.org/10.13039/100000897, Cystic Fibrosis Foundation;
Award ID: ARMBRU22F5
Award Recipient
:
Catherine R. Armbruster
Funded by:
funder-id http://dx.doi.org/10.13039/100000050, National Heart, Lung, and Blood Institute;
Award ID: T32HL129949
Award Recipient
:
Catherine R. Armbruster
Funded by:
funder-id http://dx.doi.org/10.13039/100000897, Cystic Fibrosis Foundation;
Award ID: BOMBER21P0
Award Recipient
:
ORCID: https://orcid.org/0000-0003-4767-6238
Jennifer M. Bomberger
This work was supported by a Cystic Fibrosis Foundation (CFF,
www.cff.org) Postdoctoral Fellowship ZAMORA20F0 and National Institute of Health (NIH,
www.nih.org) grant T32AI060525 to P.F.Z.; CFF grants ARMBRU19F0 and ARMBRU22F5 and NIH grant
T32HL129949 to C.R.A; and CFF grant BOMBER21P0 to J.M.B. The funders of this work
did not play a role in the study design, data collection and analysis, decision to
publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Bacteriophages
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Epithelium
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Epithelium
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Cytokines
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune System
Subject:
Innate Immune System
Subject:
Cytokines
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune System
Subject:
Innate Immune System
Subject:
Cytokines
Subject:
Biology and Life Sciences
Subject:
Developmental Biology
Subject:
Molecular Development
Subject:
Cytokines
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Bacterial Pathogens
Subject:
Pseudomonas Aeruginosa
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Bacterial Pathogens
Subject:
Pseudomonas Aeruginosa
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Bacteria
Subject:
Pseudomonas
Subject:
Pseudomonas Aeruginosa
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Cancer Treatment
Subject:
Cytokine Therapy
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Epithelial Cells
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Epithelium
Subject:
Epithelial Cells
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Epithelium
Subject:
Epithelial Cells
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Vaccination and Immunization
Subject:
Antiviral Therapy
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Vaccination and Immunization
Subject:
Antiviral Therapy
Subject:
Medicine and Health Sciences
Subject:
Public and Occupational Health
Subject:
Preventive Medicine
Subject:
Vaccination and Immunization
Subject:
Antiviral Therapy
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Physiological Processes
Subject:
Secretion