Unusual thermogelling behaviour of poly[2-(dimethylamino)ethyl methacrylate] (PDMAEMA)-based polymers polymerized in bulk

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Abstract

The bulk synthesis of (PDMAEMA)-based polymers and their unusual thermoreversible gelation in aqueous solutions are described.

Abstract

The bulk synthesis of (PDMAEMA)-based polymers and their unusual thermoreversible gelation in aqueous solutions are described. Herein we show the structure–property relationship between the sol-to-gel phase transition on the polymer characteristics and molecular weight. The tunable sensitivity of these supramolecular sol–gel reversible hydrogels are further described.

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Hydrogels in pharmaceutical formulations.

N. Peppas (2000)

The availability of large molecular weight protein- and peptide-based drugs due to the recent advances in the field of molecular biology has given us new ways to treat a number of diseases. Synthetic hydrogels offer a possibly effective and convenient way to administer these compounds. Hydrogels are hydrophilic, three-dimensional networks, which are able to imbibe large amounts of water or biological fluids, and thus resemble, to a large extent, a biological tissue. They are insoluble due to the presence of chemical (tie-points, junctions) and/or physical crosslinks such as entanglements and crystallites. These materials can be synthesized to respond to a number of physiological stimuli present in the body, such as pH, ionic strength and temperature. The aim of this article is to present a concise review on the applications of hydrogels in the pharmaceutical field, hydrogel characterization and analysis of drug release from such devices.