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      Complex regulation of CCR9 at multiple discrete stages of T cell development.

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          Abstract

          We have conducted a comprehensive assessment of CCR9 expression and function at the important milestone stages of murine thymocyte development. We reveal an unusually complex regulatory pattern, in which CCR9 influences T cell development at several widely dispersed stages. We find that CCR9 is not expressed within the thymus until the double-negative (DN)3 stage, although it appears to contribute to T cell precursor development prior to residence in the thymus. CCR9 expression is influenced by pre-T cell receptor signals, and is dramatically up-regulated in a population that appears to be transitional between the DN4 and double-positive stages. In the periphery, functional CCR9 is expressed by all naive CD8 T cells, but not by naive CD4 T cells. To our knowledge, this latter finding is the first difference observed in homing receptor expression between naive lymphocyte populations. This suggests that naive CD8 T cells might have access to lymphoid microenvironments from which naive CD4 T cells are excluded.

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          Author and article information

          Journal
          Eur. J. Immunol.
          European journal of immunology
          Wiley-Blackwell
          0014-2980
          0014-2980
          Jan 2006
          : 36
          : 1
          Affiliations
          [1 ] Joint Program in Transfusion Medicine, Children's Hospital, Boston, MA 02115, USA. marc-andre.wurbel@childrens.harvard.edu
          Article
          10.1002/eji.200535203
          16342233
          50f18c9c-bbc1-4cad-a903-1a7d406c209b
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