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      African smallholder farmers and the treatment of livestock diseases using ethnoveterinary medicine: A commentary

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          Abstract

          Often touted as an ancient and sustainable practice among indigenous livestock farmers in developing countries, the use of ethno-veterinary medicine is examined within the context of its efficacy. While there are undoubtedly positive implications for adopting knowledge and practice that align with nature, there is both prevalence and ambivalence to the adoption of indigenous plant knowledge and resources for the treatment of livestock infections and diseases. This situation is due to the lack of validation and standardization of the practice in low-income countries, requiring scholarly efforts in developing this indigenous knowledge system. This is a short communication piece that provides a commentary on the issues that pertain to ethno-veterinary practice among rural livestock farmers in sub-Saharan Africa.

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          Food animals and antimicrobials: impacts on human health.

          Antimicrobials are valuable therapeutics whose efficacy is seriously compromised by the emergence and spread of antimicrobial resistance. The provision of antibiotics to food animals encompasses a wide variety of nontherapeutic purposes that include growth promotion. The concern over resistance emergence and spread to people by nontherapeutic use of antimicrobials has led to conflicted practices and opinions. Considerable evidence supported the removal of nontherapeutic antimicrobials (NTAs) in Europe, based on the "precautionary principle." Still, concrete scientific evidence of the favorable versus unfavorable consequences of NTAs is not clear to all stakeholders. Substantial data show elevated antibiotic resistance in bacteria associated with animals fed NTAs and their food products. This resistance spreads to other animals and humans-directly by contact and indirectly via the food chain, water, air, and manured and sludge-fertilized soils. Modern genetic techniques are making advances in deciphering the ecological impact of NTAs, but modeling efforts are thwarted by deficits in key knowledge of microbial and antibiotic loads at each stage of the transmission chain. Still, the substantial and expanding volume of evidence reporting animal-to-human spread of resistant bacteria, including that arising from use of NTAs, supports eliminating NTA use in order to reduce the growing environmental load of resistance genes.
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            Use of antimicrobials in food animals and impact of transmission of antimicrobial resistance on humans

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              Potential roles of medicinal plants for the treatment of viral diseases focusing on COVID ‐19: A review

              The whole world is entangled by the coronavirus disease (COVID‐19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), people are dying in thousands each day, and without an actual medication, it seems not possible for the bringing this global health crisis to a stop. Natural products have been in constant use since ancient times and are proven by time to be effective. Crude extract or pure compounds isolated from medicinal plants and/or herbs such as Artemisia annua, Agastache rugosa, Astragalus membranaceus, Cassia alata, Ecklonia cava, Gymnema sylvestre, Glycyrrhizae uralensis, Houttuynia cordata, Lindera aggregata, Lycoris radiata, Mollugo cerviana, Polygonum multiflorum, Pyrrosia lingua, Saposhnikoviae divaricate, Tinospora cordifolia etc. have shown promising inhibitory effect against coronavirus. Several molecules, including acacetin, amentoflavone, allicin, blancoxanthone, curcumin, daidzein, diosmin, epigallocatechin‐gallate, emodin, hesperidin, herbacetin, hirsutenone, iguesterin, jubanine G, kaempferol, lycorine, pectolinarin, phloroeckol, silvestrol, tanshinone I, taxifolin, rhoifolin, xanthoangelol E, zingerol etc. isolated from plants could also be potential drug candidates against COVID‐19. Moreover, these could also show promising inhibitory effects against influenza‐parainfluenza viruses, respiratory syncytial virus, severe acute respiratory syndrome (SARS), and Middle East respiratory syndrome coronavirus (MERS‐CoV). Here, we have reported 93 antiviral drug candidates which could be a potential area of research in drug discovery.
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                Author and article information

                Contributors
                inwafor@cut.ac.za
                Journal
                Pastoralism
                Pastoralism
                Pastoralism
                Springer Berlin Heidelberg (Berlin/Heidelberg )
                2041-7136
                30 June 2022
                30 June 2022
                2022
                : 12
                : 1
                : 29
                Affiliations
                [1 ]GRID grid.428369.2, ISNI 0000 0001 0245 3319, Centre for Applied Food Sustainability and Biotechnology, , Central University of Technology, Free State, ; Bloemfontein, South Africa
                [2 ]GRID grid.428369.2, ISNI 0000 0001 0245 3319, Department of Agriculture, , Central University of Technology, Free State, ; Bloemfontein, South Africa
                Author information
                http://orcid.org/0000-0002-9321-925X
                Article
                244
                10.1186/s13570-022-00244-6
                9244877
                516e72e4-61fa-40c8-a3c0-7f2e1595a07f
                © The Author(s) 2022

                Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 27 October 2021
                : 12 May 2022
                Categories
                Commentary
                Custom metadata
                © The Author(s) 2022

                ethno-veterinary medicine,efficacy,livestock infections,treatment,smallholder farmer,indigenous plant knowledge,sub-saharan africa

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