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The role of E-cadherin down-regulation in oral cancer: CDH1 gene expression and epigenetic blockage.
G Pannone ,
A Santoro ,
A Feola ,
P Bufo ,
P Papagerakis ,
L Lo Muzio ,
S Staibano ,
F Ionna ,
F Longo ,
R Franco ,
G Aquino ,
M Contaldo ,
S De Maria ,
R Serpico ,
A De Rosa ,
C Rubini ,
S Papagerakis ,
A Giovane ,
V Tombolini ,
A Giordano ,
M Caraglia ,
M Di Domenico
1
2014
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Abstract
The prognosis of the oral squamous cell carcinoma (OSCC) patients remains very poor, mainly due to their high propensity to invade and metastasize. E-cadherin reduced expression occurs in the primary step of oral tumour progression and gene methylation is a mode by which the expression of this protein is regulated in cancers. In this perspective, we investigated E-cadherin gene (CDH1) promoter methylation status in OSCC and its correlation with Ecadherin protein expression, clinicopathological characteristics and patient outcome.