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      Loop gain predicts the response to upper airway surgery in patients with obstructive sleep apnoea: Ventilatory control abnormalities predict surgical responsiveness.

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          Abstract

          Upper airway surgery is often recommended to treat OSA patients who cannot tolerate continuous positive airways pressure (CPAP). However, the response to surgery is variable, potentially because it does not improve the non-anatomical factors (i.e. loop gain and arousal threshold) causing OSA. Measuring these traits clinically might predict responses to surgery. Our primary objective was to test the value of loop gain and arousal threshold to predict surgical success defined as 50% reduction in apnea-hypopnea index (AHI) and AHI <10 events/hr post-surgery.

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          Author and article information

          Journal
          Sleep
          Sleep
          Oxford University Press (OUP)
          1550-9109
          0161-8105
          May 22 2017
          Affiliations
          [1 ] Monash Lung and Sleep, Monash Medical Centre, Clayton, VIC, Australia.
          [2 ] School of Clinical Sciences, Monash University, Melbourne, VIC, Australia.
          [3 ] Sleep and Circadian Medicine Laboratory, Department of Physiology Monash University, Melbourne, VIC, Australia.
          [4 ] Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham & Women's Hospital & Harvard Medical School, Boston, MA, USA.
          [5 ] Department of Allergy, Immunology and Respiratory Medicine and Central Clinical School, The Alfred and Monash University, Melbourne, VIC, Australia.
          [6 ] School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Australia.
          [7 ] The Ear, Nose and Throat/Head and Neck Surgery Unit, Monash Health, Melbourne, VIC, Australia. Department of Surgery, School of Clinical Science at Monash Health, Monash University.
          [8 ] School of Psychological Sciences and Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Melbourne, VIC, Australia.
          Article
          3845961
          10.1093/sleep/zsx094
          28531336
          529c791f-eb5e-4a7c-a104-9e4482001310
          History

          obstructive sleep apnea,surgery.,upper-airway physiology,ventilatory control

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