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      Protective effect of Co-enzyme Q10 On doxorubicin-induced cardiomyopathy of rat hearts.

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          Abstract

          Q10 is a powerful antioxidant often used in medical nutritional supplements for cancer treatment. This study determined whether Q10 could effectively prevent cardio-toxicity caused by doxorubicin treatment. Four week old SD rats were segregated into groups namely control, doxorubicin group (challenged with doxorubicin), Dox + Q10 group (with doxorubicin challenge and oral Q10 treatment), and Q10 group (with oral Q10 treatment). Doxorubicin groups received IP doxorubicin (2.5 mg/kg) every 3 days and Q10 groups received Q10 (10 mg/kg) every day. Three weeks of doxorubicin challenge caused significant reduction in heart weight, disarray in cardiomyocyte arrangement, elevation of collagen accumulation, enhancement of fibrosis and cell death associated proteins, and inhibition of survival proteins. However, Q10 effectively protected cardiomyocytes and ameliorated fibrosis and cell death induced by doxorubicin. Q10 is, therefore, evidently a potential drug to prevent heart damage caused by doxorubicin. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 679-689, 2017.

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          Author and article information

          Journal
          Environ. Toxicol.
          Environmental toxicology
          Wiley-Blackwell
          1522-7278
          1520-4081
          Feb 2017
          : 32
          : 2
          Affiliations
          [1 ] Department of Pathology, China Medical University Hospital, Taichung, Taiwan.
          [2 ] Department of Sports Sciences, University of Taipei, Taipei, Taiwan.
          [3 ] Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.
          [4 ] Department of Nursing, MeiHo University, Pingtung, Taiwan.
          [5 ] Division of Cardiology, China Medical University Hospital, Taichung, Taiwan.
          [6 ] Department of Biotechnology, Asia University, Taichung, Taiwan.
          [7 ] Department of Biotechnology, Bharathiar University, Coimbatore, 641 046, India.
          [8 ] Graduate Institute of Chinese Medicine, China Medical University, Taichung, Taiwan.
          [9 ] Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan.
          Article
          10.1002/tox.22270
          27087047
          53203bb2-352c-45a3-8047-7eafbd2aab8a
          History

          coenzyme Q10,cardiac fibrosis,cardio-toxicity,cardiac apoptosis

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