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Clinical and genetic determinants of plasma nevirapine exposure following an intrapartum dose to prevent mother-to-child HIV transmission.
Saran Vardhanabhuti
1 ,
Edward P Acosta ,
Heather J Ribaudo ,
Patrice Severe ,
Umesh Lalloo ,
Nagalingeshwaran Kumarasamy ,
Frank Taulo ,
Joseph Kabanda ,
Olola Oneko ,
Prudence Ive ,
Pradeep Sambarey ,
Ellen S Chan ,
Jane Hitti ,
Francis Hong ,
Deborah McMahon ,
David W Haas
Aug 15 2013
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Abstract
Nevirapine is metabolized by cytochrome P450 (CYP) 2B6 and CYP3A4. We characterized relationships between clinical parameters, human genetics, pharmacokinetics, and human immunodeficiency virus type 1 (HIV-1) drug resistance mutations in pregnant women following single-dose intrapartum nevirapine.