Organophotoredox-Catalyzed Direct C-H Amination of 2H-Indazoles with Amines.

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Abstract

A general and practical method for the direct C-H amination of 2H-indazoles with a series of amines including aliphatic primary amines, secondary amines, azoles, and sulfoximines via organophotoredox-catalyzed oxidative coupling has been disclosed at room temperature under ambient air conditions. Additionally, this protocol is used for free aminated 2H-indazole synthesis. A mechanistic study revealed that a single electron transfer (SET) pathway might be involved in this reaction.

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Journal

Journal ID (iso-abbrev): Org Lett

Title: Organic letters

Publisher: American Chemical Society (ACS)

ISSN (Electronic): 1523-7052

ISSN (Print): 1523-7052

Publication date (Electronic): July 17 2020

Volume: 22

Issue: 14

Affiliations

[1 ] Department of Chemistry, Visva-Bharati (A Central University), Santiniketan 731235, India.

[2 ] Integrated Science Education & Research Centre, Visva-Bharati (A Central University), Santiniketan 731235, India.

Article

DOI: 10.1021/acs.orglett.0c01973

PubMed ID: 32578430

SO-VID: 53ccc743-4066-494e-8c16-996c19f6b98c

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