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Effect of Shosaikoto on plasma catecholamines
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Abstract
Plasma adrenaline (AD) and noradrenaline (NA) were determined using high performance
liquid chromatography (HPLC) equipped with an electrochemical detector. In an experiment
using non-treated adrenalectomized rats, most plasma AD appeared to originate from
the adrenal medulla, while plasma NA came from other sites. When Shosaikoto, a Japanese
and Chinese traditional medicinal mixture, was orally administered to rats, plasma
AD levels decreased in a significant manner 60 min after treatment, while plasma NA
levels were not changed. Pretreatment with pentobarbital inhibited the Shosaikoto-induced
decrease of plasma AD levels.