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      Metabolomics Investigation To Shed Light on Cheese as a Possible Piece in the French Paradox Puzzle

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          Abstract

          An NMR-based metabolomics approach was used to investigate the differentiation between subjects consuming cheese or milk and to elucidate the potential link to an effect on blood cholesterol level. Fifteen healthy young men participated in a full crossover study during which they consumed three isocaloric diets with similar fat contents that were either (i) high in milk, (ii) high in cheese with equal amounts of dairy calcium, or (iii) a control diet for 14 days. Urine and feces samples were collected and analyzed by NMR-based metabolomics. Cheese and milk consumption decreased urinary choline and TMAO levels and increased fecal excretion of acetate, propionate, and lipid. Compared with milk intake, cheese consumption significantly reduced urinary citrate, creatine, and creatinine levels and significantly increased the microbiota-related metabolites butyrate, hippurate, and malonate. Correlation analyses indicated that microbial and lipid metabolism could be involved in the dairy-induced effects on blood cholesterol level.

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          Author and article information

          Journal
          Journal of Agricultural and Food Chemistry
          J. Agric. Food Chem.
          American Chemical Society (ACS)
          0021-8561
          1520-5118
          March 10 2015
          March 18 2015
          March 10 2015
          March 18 2015
          : 63
          : 10
          : 2830-2839
          Affiliations
          [1 ]Department of Food Science, Aarhus University, Kirstinebjergvej 10, DK-5792 Aarslev, Denmark
          [2 ]Department of Nutrition, Exercise and Sports, University of Copenhagen, DK-1958 Frederiksberg C, Denmark
          Article
          10.1021/jf505878a
          25727903
          © 2015
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