Recent developments in the application of comprehensive two-dimensional gas chromatography.

The literature on comprehensive two-dimensional gas chromatography (GC x GC) is reviewed, with emphasis on application-oriented studies published in the period 2004-2006. The various strategies that can be used in such studies, the state-of-the-art analytical performance and the high potential of GC x GC combined with time-of-flight mass spectrometric detection are highlighted.