Tissue and cellular characterisation of nucleolin in a murine model of corneal angiogenesis.

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Abstract

Corneal neovascularisation (CNV), with consequent loss of transparency, is due to an imbalance of proangiogenic factors. Cell-surface nucleolin (NCL) has been associated with neo-angiogenesis. There are studies identifying NCL translocation from nucleus to the cell surface, which is essential for endothelial cell proliferation. To find the possible role of NCL in the generation of corneal neovessels, the aim of this study is to characterise the NCL presence and cell-localisation in non-injured corneas, as well as to describe the changes in NCL cell and tissue localisation in CNV, and to analyse the effect of bevacizumab on NCL cellular and tissular distribution.

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Journal

Journal ID (iso-abbrev): Graefes Arch Clin Exp Ophthalmol

Title: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1435-702X

ISSN (Print): 0721-832X

Publication date (Electronic): Sep 2016

Volume: 254

Issue: 9

Affiliations

[1 ] Research Unit, Institute of Ophthalmology Conde de Valenciana Foundation, Chimalpopoca 14, 06800, Mexico City, Mexico.

[2 ] Faculty of Veterinary Medicine and Animal Husbandry, Universidad Nacional Autónoma de México, Avenida Universidad 3000, 04510, Mexico City, Mexico.

[3 ] Department of Biochemistry, Faculty of Medicine, Universidad Nacional Autónoma de México, Avenida Universidad 3000, 04510, Mexico City, Mexico.

[4 ] Research Unit, Institute of Ophthalmology Conde de Valenciana Foundation, Chimalpopoca 14, 06800, Mexico City, Mexico. yogarfias@institutodeoftalmologia.org.

[5 ] Department of Biochemistry, Faculty of Medicine, Universidad Nacional Autónoma de México, Avenida Universidad 3000, 04510, Mexico City, Mexico. yogarfias@institutodeoftalmologia.org.

Article

Publisher Item ID: 10.1007/s00417-016-3409-8

DOI: 10.1007/s00417-016-3409-8

PubMed ID: 27313162

SO-VID: 56827dc7-0c38-4f31-b61c-dcbece0679f1

History

Keywords: Angiogenesis,Cornea,Nucleolin

Data availability:

Keywords: Angiogenesis, Cornea, Nucleolin

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