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      • Record: found
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      Complete Regression of a Melanocytic Nevus under Intense Pulsed Light Therapy for Axillary Hair Removal in a Cosmetic Center

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          Abstract

          Intense pulsed light (IPL) therapy using noncoherent broad-spectrum light has been reported to be effective for hair removal, and also for treating superficial pigmented lesions like ephelides and solar lentigines. We report complete regression of a pigmented melanocytic nevus, histologically confirmed, after hair removal treatment with IPL. The use of lasers and IPL is a common procedure used by dermatologists and even other professions for the treatment of cosmetically troubling skin conditions. The main advantage of such treatment is a reduction of surgical scars, thus producing a favorable cosmetic outcome, but a major limitation is that histopathologic diagnosis is not usually obtained prior to treatment. Such devices should be carefully used in patients with potentially dangerous melanocytic lesions. We also review the recent literature regarding inadequate treatment of melanocytic lesions with lasers.

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          Professional errors caused by lasers and intense pulsed light technology in dermatology and aesthetic medicine: preventive strategies and case studies.

          Mette Greve, Christian Raulin (2002)
          The use of lasers and intense pulsed light (IPL) technology has become established practice in dermatology and aesthetic medicine. The increase in popularity and widespread use of such equipment has been accompanied by a sharp increase in the number of case reports about professional errors. We present 14 case studies of professional errors. Selected representative case reports are used to illustrate and discuss typical professional errors and serve as the basis for creating preventive strategies. Recommendations have been developed for the following areas: physician training, patient information, documentation, diagnosis, indication, test treatment, and performing treatment. The use of lasers and IPL technology in dermatology and aesthetic medicine requires practitioners not only to have high levels of training and experience, but also to exercise professional judgment. In spite of all of the precautions taken, the risk of complications and side effects can be reduced but not completely eliminated.
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            Non-invasive visualization of melanin and melanocytes by reflectance-mode confocal microscopy.

            Toyonobu Yamashita, Tomohiro Kuwahara, Salvador Gonzalez … (2005)
            In vivo visualization of epidermal melanin was performed by reflectance-mode confocal microscopy (RCM). Firstly, we examined the distribution of epidermal melanin in pigmented animals and compared with that of the human skin. Melanocytes in the skin of pigmented animals were found to accumulate a large amount of melanin that can be easily visualized because of its brightness. Their RCM images correlated well with the Fontana-Masson-stained sections for melanin. In contrast, in the human skin, typical dendritic melanocytes were hardly observed even in pigmented lesions, although supranuclear melanin caps were easily visible. These results suggested that human melanocytes rapidly transfer the produced melanin to keratinocytes and do not accumulate it. Secondly, to elucidate the production of melanin by human melanocytes, we evaluated the changes of melanin after a single ultraviolet (UV) exposure. The melanin-accumulating melanocytes were clearly visualized during the skin pigmentation process. The RCM images showed the brightness because of melanin gradually increased from day 4, then dendrite-elongated melanocytes appearing from day 8, and finally melanin caps formed from day 29. In conclusion, RCM successfully evidenced the difference in melanin distribution between the pigmented animals and humans, and the UV-induced pigmentation process in vivo as well.
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              Clinical improvement of solar lentigines and ephelides with an intense pulsed light source.

              H. Shiraishi, Hiroko Kameyama, T Tezuka … (2002)
              A noncoherent, broadband, intense pulsed light (IPL) source has been used for the symptoms of photoaging skin as a nonablative method. To investigate the efficacy and tolerability of IPL in solar lentigines and ephelides on the face. An open study was performed in patients with solar lentigines and ephelides who received three to five treatments of IPL. Forty-eight percent of patients had more than 50% improvement and 20% had more than 75% improvement. In the group of solar lentigines, 40% of patients showed more than 50% improvement and 16% had more than 75% improvement. Patients with small plaques of solar lentigines responded well, whereas patients with small + large and large plaques showed poor response. Patients with solar lentigines + ephelides and ephelides responded remarkably with 75% and 71% of patients, respectively, having more than 50% improvement. IPL was well tolerated and may be a new modality for the therapy of solar lentigines and ephelides.
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                Author and article information

                Journal
                Journal ID (publisher-id): DRM
                Journal ID (nlm-ta): Dermatology
                Journal ID (doi): 10.1159/issn.1018-8665
                Title: Dermatology
                Publisher: S. Karger AG
                ISSN (Print): 1018-8665
                ISSN (Electronic): 1421-9832
                Publication date Subscription-year: 2012
                Publication date (Print): July 2012
                Publication date (Electronic): 07 May 2012
                Volume: 224
                Issue: 3
                Pages: 193-197
                Affiliations
                Departments of aDermatology and bPathology, Hospital Clínico Universitario de Valencia, Valencia, Spain
                Author notes
                *Dr. José M. Martín, Hospital Clínico Universitario de Valencia, Avda Blasco Ibáñez, n o 17, ES–46010 Valencia (Spain), E-Mail jmmart@eresmas.com
                Article
                Publisher ID: 338573 Other ID: Dermatology 2012;224:193–197
                DOI: 10.1159/000338573
                PubMed ID: 22571959
                SO-VID: 56a03966-c4eb-4d6f-ad66-a4aa0f6b73b8
                Copyright © © 2012 S. Karger AG, Basel
                License:

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                History
                Date received : 29 April 2011
                Date accepted : 21 March 2012
                Page count
                Figures: 3, Tables: 1, Pages: 5
                Categories
                Subject: Case and Review

                ScienceOpen disciplines: Oncology & Radiotherapy,Pathology,Surgery,Dermatology,Pharmacology & Pharmaceutical medicine
                Keywords: Pseudomelanoma,Melanocytic lesions,Laser,Intense pulsed light,Regression
                Data availability:
                ScienceOpen disciplines: Oncology & Radiotherapy, Pathology, Surgery, Dermatology, Pharmacology & Pharmaceutical medicine
                Keywords: Pseudomelanoma, Melanocytic lesions, Laser, Intense pulsed light, Regression

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