- Record: found
- Abstract: found
- Article: found
Hemozoin is a potent adjuvant for hemagglutinin split vaccine without pyrogenicity in ferrets
Motoyasu Onishi ,
Mitsutaka Kitano ,
Keiichi Taniguchi ,
Tomoyuki Homma ,
Masanori Kobayashi ,
Akihiko Sato ,
Cevayir Coban ,
Ken J. Ishii
May 2014
May 2014
Read this article at
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Synthetic hemozoin (sHZ, also known as β-hematin) from monomeric heme is a particle
adjuvant which activates antigen-presenting cells (APCs), such as dendritic cells
and macrophages, and enhances humoral immune responses to several antigens, including
ovalbumin, human serum albumin, and serine repeat antigen 36 of Plasmodium falciparum.
In the present study, we evaluated the adjuvanticity and pyrogenicity of sHZ as an
adjuvant for seasonal trivalent hemagglutinin split vaccine (SV) for humans using
the experimental ferret model.