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      Welcome to Volume 2 of Future Drug Discovery

      , * , 1 , 1

      Future Drug Discovery

      Newlands Press Ltd

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          Most cited references 4

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          Polyphenol and self-assembly: metal polyphenol nanonetwork for drug delivery and pharmaceutical applications

           Xingcai Zhang (corresponding) ,  Gaurav Parekh,  Baoling Guo (2019)
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            Perlecan-targeted nanoparticles for drug delivery to triple-negative breast cancer

            Aim: We previously developed two antibodies that bind to a cell surface protein, perlecan, overexpressed in triple-negative breast cancer (TNBC). The goal of this study was to investigate these antibodies as targeting ligands for nanoparticle-mediated drug delivery. Methods: Paclitaxel-loaded poly(D,L-lactide-co-glycolide) nanoparticles were functionalized with antibodies using thiol–maleimide chemistry. Effect of antibody functionalization on therapeutic efficacy of drug-loaded nanoparticles was investigated using in vitro and in vivo models of TNBC. Results: The antibodies were covalently conjugated to nanoparticles without affecting antibody binding affinity or nanoparticle properties. Perlecan-targeted nanoparticles showed improved cell uptake, retention, cytotoxicity in vitro and enhanced tumor growth inhibition in vivo. Conclusion: The data presented here indicates that perlecan-targeted nanoparticles can improve tumor drug delivery to TNBC.
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              Now the future, we see our dreams: artificial intelligence in drug discovery

               Rae Lawrence (corresponding) (2019)
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                Author and article information

                Journal
                FDD
                Future Drug Discovery
                Future Drug. Discov.
                Future Drug Discovery
                Newlands Press Ltd (London, UK )
                2631-3316
                05 February 2020
                January 2020
                : 2
                : 1
                Affiliations
                1Future Science Group, Unitec House, 2 Albert Place, London, N3 1QB, UK
                Author notes
                [* ]Author for correspondence: f.lake@ 123456future-science.com
                10.4155/fdd-2019-0036
                © 2020 Future Science Ltd

                This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License

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