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      Multifunctional microrobot with real-time visualization and magnetic resonance imaging for chemoembolization therapy of liver cancer

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          Abstract

          Microrobots that can be precisely guided to target lesions have been studied for in vivo medical applications. However, existing microrobots have challenges in vivo such as biocompatibility, biodegradability, actuation module, and intra- and postoperative imaging. This study reports microrobots visualized with real-time x-ray and magnetic resonance imaging (MRI) that can be magnetically guided to tumor feeding vessels for transcatheter liver chemoembolization in vivo. The microrobots, composed of a hydrogel-enveloped porous structure and magnetic nanoparticles, enable targeted delivery of therapeutic and imaging agents via magnetic guidance from the actuation module under real-time x-ray imaging. In addition, the microrobots can be tracked using MRI as postoperative imaging and then slowly degrade over time. The in vivo validation of microrobot system–mediated chemoembolization was demonstrated in a rat liver with a tumor model. The proposed microrobot provides an advanced medical robotic platform that can overcome the limitations of existing microrobots and current liver chemoembolization.

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          Abstract

          Microrobot capable of targeted delivery, real-time x-ray, and magnetic resonance imaging was developed for chemoembolization.

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          Dopamine-melanin colloidal nanospheres: an efficient near-infrared photothermal therapeutic agent for in vivo cancer therapy.

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            Superparamagnetic iron oxide nanoparticles (SPIONs): development, surface modification and applications in chemotherapy.

            At present, nanoparticles are used for various biomedical applications where they facilitate laboratory diagnostics and therapeutics. More specifically for drug delivery purposes, the use of nanoparticles is attracting increasing attention due to their unique capabilities and their negligible side effects not only in cancer therapy but also in the treatment of other ailments. Among all types of nanoparticles, biocompatible superparamagnetic iron oxide nanoparticles (SPIONs) with proper surface architecture and conjugated targeting ligands/proteins have attracted a great deal of attention for drug delivery applications. This review covers recent advances in the development of SPIONs together with their possibilities and limitations from fabrication to application in drug delivery. In addition, the state-of-the-art synthetic routes and surface modification of desired SPIONs for drug delivery purposes are described. Copyright © 2010 Elsevier B.V. All rights reserved.
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              X-ray-computed tomography contrast agents.

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                Author and article information

                Contributors
                Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole: ResourcesRole: SoftwareRole: ValidationRole: VisualizationRole: Writing - original draftRole: Writing - review & editing
                Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole: ResourcesRole: ValidationRole: Writing - original draftRole: Writing - review & editing
                Role: Software
                Role: Investigation
                Role: Investigation
                Role: Validation
                Role: Methodology
                Role: ConceptualizationRole: Funding acquisitionRole: MethodologyRole: SupervisionRole: Writing - review & editing
                Role: Formal analysis
                Role: InvestigationRole: Resources
                Role: InvestigationRole: MethodologyRole: Supervision
                Role: ConceptualizationRole: MethodologyRole: ResourcesRole: ValidationRole: VisualizationRole: Writing - review & editing
                Role: InvestigationRole: Methodology
                Role: Investigation
                Role: ConceptualizationRole: Data curationRole: Funding acquisitionRole: InvestigationRole: MethodologyRole: Project administrationRole: SupervisionRole: ValidationRole: VisualizationRole: Writing - original draftRole: Writing - review & editing
                Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole: InvestigationRole: Project administrationRole: ResourcesRole: SupervisionRole: VisualizationRole: Writing - original draftRole: Writing - review & editing
                Role: ConceptualizationRole: Funding acquisitionRole: Project administrationRole: SupervisionRole: Writing - original draftRole: Writing - review & editing
                Role: ConceptualizationRole: Data curationRole: Funding acquisitionRole: MethodologyRole: Project administrationRole: ResourcesRole: SupervisionRole: VisualizationRole: Writing - original draftRole: Writing - review & editing
                Journal
                Sci Adv
                Sci Adv
                sciadv
                advances
                Science Advances
                American Association for the Advancement of Science
                2375-2548
                November 2022
                18 November 2022
                : 8
                : 46
                : eabq8545
                Affiliations
                [ 1 ]Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA.
                [ 2 ]Korea Institute of Medical Microrobotics (KIMIRo), 43-26 Cheomdangwagi-ro, Buk-gu, Gwangju 61011, Korea.
                [ 3 ]School of Mechanical Engineering, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Korea.
                [ 4 ]College of AI Convergence, Chonnam National University, Gwangju 34931, Korea.
                [ 5 ]Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-Gu, Seoul 05505, Korea.
                [ 6 ]Department of Veterinary Surgery, College of Veterinary Medicine and Biomaterial R&BD Center, Chonnam National University, Gwangju 61186, Korea.
                [ 7 ]Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul 120-752, Korea.
                [ 8 ]Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
                Author notes
                [* ]Corresponding author. Email: dhkim@ 123456jhu.edu (D.-H.K.); jop@ 123456kimiro.re.kr (J.-O.P.); eunpyochoi@ 123456jnu.ac.kr (E.C.)
                Author information
                https://orcid.org/0000-0003-2970-7221
                https://orcid.org/0000-0003-2137-3722
                https://orcid.org/0000-0003-1260-3610
                https://orcid.org/0000-0002-5811-3505
                https://orcid.org/0000-0003-1185-1911
                https://orcid.org/0000-0003-4532-2006
                https://orcid.org/0000-0003-3971-0475
                https://orcid.org/0000-0001-7848-5923
                https://orcid.org/0000-0002-8957-0354
                https://orcid.org/0000-0002-2273-6655
                https://orcid.org/0000-0001-6626-0786
                https://orcid.org/0000-0001-5209-8351
                https://orcid.org/0000-0002-6989-6074
                https://orcid.org/0000-0001-5362-2661
                https://orcid.org/0000-0002-9689-6520
                Article
                abq8545
                10.1126/sciadv.abq8545
                9674283
                36399561
                597926af-ac46-43ee-866c-adefda64562f
                Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

                This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.

                History
                : 05 May 2022
                : 30 September 2022
                Funding
                Funded by: FundRef http://dx.doi.org/10.13039/501100003710, Korea Health Industry Development Institute;
                Award ID: HI19C0642
                Categories
                Research Article
                Physical and Materials Sciences
                SciAdv r-articles
                Engineering
                Materials Science
                Engineering
                Custom metadata
                Adrienne Del Mundo

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