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      Exercise training in patients with corrected tetralogy of Fallot : A protocol for systematic review and meta-analysis

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          Abstract

          Background:

          The arrival of transcatheter mitral valve therapies has provided feasible and safe alternatives to medical and surgical treatments for mitral regurgitation. The aim of this study is to estimate the relative efficacy and safety of exercise training in patients with corrected tetralogy of Fallot through meta-analysis.

          Methods

          : A systematic search will be performed using PubMed, EMBASE, the Cochrane Library, Web of Science, CBM, CNKI, WanFang Data, and VIP to include random controlled trials or nonrandom controlled trials comparing the efficacy and safety of exercise training in corrected tetralogy of Fallot patients. The risk of bias for the included nonrandom controlled studies will be evaluated according to Risk of Bias in Nonrandomized Studies of Interventions. We will use the Cochrane Collaboration's tool (version 2 of the Cochrane risk of bias tool for randomized trials) to assess risk of bias of included random controlled trials. Revman 5.4 and STATA 15.0 will be used to complete the meta-analysis and generate forest plots. Grading of recommendations assessment, development, and evaluation will be used to assess the quality of evidence.

          Results

          : The results of this systematic review and meta-analysis will be submitted to a peer-reviewed journal for publication.

          Conclusion

          : This study will provide broad evidence of efficacy and safety of exercise training in patients with corrected tetralogy of Fallot and provide suggestions for clinical practice and future research.

          Protocol registration number:

          INPLASY202150006.

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          Most cited references33

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          Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement

          David Moher, Larissa Shamseer, Mike Clarke … (2017)
          Systematic reviews should build on a protocol that describes the rationale, hypothesis, and planned methods of the review; few reviews report whether a protocol exists. Detailed, well-described protocols can facilitate the understanding and appraisal of the review methods, as well as the detection of modifications to methods and selective reporting in completed reviews. We describe the development of a reporting guideline, the Preferred Reporting Items for Systematic reviews and Meta-Analyses for Protocols 2015 (PRISMA-P 2015). PRISMA-P consists of a 17-item checklist intended to facilitate the preparation and reporting of a robust protocol for the systematic review. Funders and those commissioning reviews might consider mandating the use of the checklist to facilitate the submission of relevant protocol information in funding applications. Similarly, peer reviewers and editors can use the guidance to gauge the completeness and transparency of a systematic review protocol submitted for publication in a journal or other medium.
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            ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions

            Jonathan AC Sterne, Miguel A. Hernán, Barnaby Reeves … (2018)
            Non-randomised studies of the effects of interventions are critical to many areas of healthcare evaluation, but their results may be biased. It is therefore important to understand and appraise their strengths and weaknesses. We developed ROBINS-I (“Risk Of Bias In Non-randomised Studies - of Interventions”), a new tool for evaluating risk of bias in estimates of the comparative effectiveness (harm or benefit) of interventions from studies that did not use randomisation to allocate units (individuals or clusters of individuals) to comparison groups. The tool will be particularly useful to those undertaking systematic reviews that include non-randomised studies.
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              Birth prevalence of congenital heart disease worldwide: a systematic review and meta-analysis.

              Denise van der Linde, Elisabeth E M Konings, Maarten A Slager … (2011)
              Congenital heart disease (CHD) accounts for nearly one-third of all major congenital anomalies. CHD birth prevalence worldwide and over time is suggested to vary; however, a complete overview is missing. This systematic review included 114 papers, comprising a total study population of 24,091,867 live births with CHD identified in 164,396 individuals. Birth prevalence of total CHD and the 8 most common subtypes were pooled in 5-year time periods since 1930 and in continent and income groups since 1970 using the inverse variance method. Reported total CHD birth prevalence increased substantially over time, from 0.6 per 1,000 live births (95% confidence interval [CI]: 0.4 to 0.8) in 1930 to 1934 to 9.1 per 1,000 live births (95% CI: 9.0 to 9.2) after 1995. Over the last 15 years, stabilization occurred, corresponding to 1.35 million newborns with CHD every year. Significant geographical differences were found. Asia reported the highest CHD birth prevalence, with 9.3 per 1,000 live births (95% CI: 8.9 to 9.7), with relatively more pulmonary outflow obstructions and fewer left ventricular outflow tract obstructions. Reported total CHD birth prevalence in Europe was significantly higher than in North America (8.2 per 1,000 live births [95% CI: 8.1 to 8.3] vs. 6.9 per 1,000 live births [95% CI: 6.7 to 7.1]; p < 0.001). Access to health care is still limited in many parts of the world, as are diagnostic facilities, probably accounting for differences in reported birth prevalence between high- and low-income countries. Observed differences may also be of genetic, environmental, socioeconomical, or ethnic origin, and there needs to be further investigation to tailor the management of this global health problem. Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Medicine (Baltimore)
                Journal ID (iso-abbrev): Medicine (Baltimore)
                Journal ID (publisher-id): MEDI
                Title: Medicine
                Publisher: Lippincott Williams & Wilkins (Hagerstown, MD )
                ISSN (Print): 0025-7974
                ISSN (Electronic): 1536-5964
                Publication date Collection: 28 May 2021
                Publication date (Electronic): 28 May 2021
                Volume: 100
                Issue: 21
                Electronic Location Identifier: e26108
                Affiliations
                [a ]Department of Cardiovascular Surgery, Gansu Provincial Hospital
                [b ]Congenital Heart Disease Diagnosis and Treatment Gansu Province International Science and Technology Cooperation Base, Lanzhou
                [c ]Department of Thoracic Surgery, The First Hospital of Longnan City, Longnan, China.
                Author notes
                [∗ ]Correspondence: Ya-Qin Gong, Department of Cardiovascular Surgery, Gansu Provincial Hospital, No. 204, Donggang West Road, Lanzhou City, Gansu Province 730000, China (e-mail: gongyq20@ 123456126.com ).
                Article
                Publisher ID: MD-D-21-03398 Accession ID: 26108
                DOI: 10.1097/MD.0000000000026108
                PMC ID: 8154459
                PubMed ID: 34032753
                SO-VID: 5a7928c8-2c19-4a9b-bb27-636f905bc9f7
                Copyright © Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
                License:

                This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0

                History
                Date received : 5 May 2021
                Date accepted : 7 May 2021
                Funding
                Funded by: Natural Science Foundation of Gansu Province
                Award ID: 21JR1RA027
                Award Recipient : Ya-Qin Gong
                Funded by: Health Industry Scientific Research Project of Gansu Province
                Award ID: GSWSKY2016-04
                Award Recipient : Ya-Qin Gong
                Categories
                Subject: 3400
                Subject: Research Article
                Subject: Study Protocol Systematic Review
                Custom metadata
                OPEN-ACCESS TRUE

                Keywords: congenital heart disease,exercise training,meta-analysis,systematic review,tetralogy of fallot
                Data availability:
                Keywords: congenital heart disease, exercise training, meta-analysis, systematic review, tetralogy of fallot

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