Paula van Dommelen:
ORCID: http://orcid.org/0000-0001-5546-6244
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: SoftwareRole: ValidationRole: VisualizationRole: Writing – original
draftRole: Writing – review & editing
Ekaterina Koledova: Role: ConceptualizationRole: Funding acquisitionRole: MethodologyRole: Project administrationRole:
ResourcesRole: SupervisionRole: Writing – review & editing
Jan M. Wit: Role: ConceptualizationRole: MethodologyRole: SupervisionRole: Writing – original
draftRole: Writing – review & editing
David Meyre: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
24
October
2018
Publication date Collection: 2018
Volume: 13
Issue: 10
Electronic Location Identifier: e0206009
Affiliations
[1
]
Department of Child Health, TNO, Leiden, The Netherlands
[2
]
Global Medical, Safety & CMO, Merck KGaA, Darmstadt, Germany
[3
]
Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
McMaster University, CANADA
Author notes
Competing Interests: The authors have read the journal's policy and the authors of this manuscript have
the following competing interests: PvD and JMW have consultancy agreements with Merck;
EK is an employee of Merck KGaA, Darmstadt, Germany.
Author information
Article
Publisher ID:
PONE-D-18-21145
DOI: 10.1371/journal.pone.0206009
PMC ID: 6200242
PubMed ID: 30356273
SO-VID: 5a95b437-a342-4729-9c77-c5b6ae73017d
Copyright © © 2018 van Dommelen et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
This study was sponsored by Merck KGaA, Darmstadt, Germany. Medical writing assistance
was provided by David Candlish, inScience Communications, Tattenhall, UK, and sponsored
by Merck KGaA, Darmstadt, Germany. The data collection was performed via the easypodTM
electronic drug-delivery device, which is a product of Merck KGaA. Also, physician
data entry of outcome measures were retrospectively and prospectively collected by
Merck KGaA. This data collection was part of the ECOS study, which was conducted in
accordance with the principles of the Declaration of Helsinki, Good Clinical Practice
(ICH-GCP E6) guidelines and applicable national legal and regulatory requirements.
The ECOS study was published in Endocrine Connections (Koledova E, Stoyanov G, Ovbude
L, Davies PSW (2018) Adherence and long-term growth outcomes: results from the easypod™
connect observational study (ECOS) in paediatric patients with growth disorders. Endocr
Connect. 7: 914-923). Post hoc analysis on the ECOS study was performed by PvD from
TNO. TNO is an independent RTO from the Netherlands founded by law. TNO’s professionals
put their knowledge and experience to work in creating smart solutions to complex
issues. These innovations help to sustainably strengthen social wellbeing and industrial
competitiveness. The core values of TNO are integrity, independence, professionalism,
and engagement with society. TNO’s Code of Conduct, published on the website of TNO
(
https://www.tno.nl/en/about-tno/mission-and-strategy/tno-code), contains a chapter on scientific integrity. Research is conducted without any undue
influence from commercial or other interests. Merck KGaA provided support in the form
of salaries for author PvD, but did not have any additional role in performing the
post hoc analysis. Merck has provided the ECOS data to TNO for this post hoc analysis.
Manuscript was reviewed according to Merck publication procedures. The specific roles
of all authors are articulated in the ‘author contributions’ section.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Hormones
Subject:
Peptide Hormones
Subject:
Growth Hormone
Subject:
Physical Sciences
Subject:
Mathematics
Subject:
Algebra
Subject:
Polynomials
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Physiological Parameters
Subject:
Body Weight
Subject:
Birth Weight
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Physiological Parameters
Subject:
Body Weight
Subject:
Birth Weight
Subject:
People and Places
Subject:
Population Groupings
Subject:
Professions
Subject:
Medical Personnel
Subject:
Medical Doctors
Subject:
Physicians
Subject:
Medicine and Health Sciences
Subject:
Health Care
Subject:
Health Care Providers
Subject:
Medical Doctors
Subject:
Physicians
Subject:
Physical Sciences
Subject:
Physics
Subject:
Classical Mechanics
Subject:
Deceleration
Subject:
Research and Analysis Methods
Subject:
Research Design
Subject:
Observational Studies
Subject:
Research and Analysis Methods
Subject:
Mathematical and Statistical Techniques
Subject:
Statistical Methods
Subject:
Regression Analysis
Subject:
Linear Regression Analysis
Subject:
Physical Sciences
Subject:
Mathematics
Subject:
Statistics
Subject:
Statistical Methods
Subject:
Regression Analysis
Subject:
Linear Regression Analysis
Subject:
Research and Analysis Methods
Subject:
Mathematical and Statistical Techniques
Subject:
Statistical Methods
Subject:
Forecasting
Subject:
Physical Sciences
Subject:
Mathematics
Subject:
Statistics
Subject:
Statistical Methods
Subject:
Forecasting
