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      Correlation between Histological Changes and Loss of Anionic Charge of the Glomerular Basement Membrane in Early-Onset Pre-Eclampsia

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          Abstract

          This study morphometrically evaluates the glomerular anionic charge and examines the renal pathology in African women with early-onset pre-eclampsia. Polyethyleneimine-labelled anionic sites were decreased within the glomerular basement membrane in the early-onset pre-eclampsia group as compared with the control group (p < 0.02). A strong correlation (r = -0.76) was obtained between the number of anionic sites and the severity of proteinuria. Renal biopsy specimens revealed the coexistence of decreased glomerular charge with pathology of glomerular basement membrane, endothelial cells, foot processes, and mesangial cell proliferation. The loss of glomerular charge induces structural alterations of the glomerular filtration barrier and may be the mechanism responsible for proteinuria in early-onset pre-eclampsia.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1997
          1997
          19 December 2008
          : 75
          : 2
          : 201-207
          Affiliations
          aElectron Microscope Unit, Departments of bMedicine and cPharmacology, and dMRC Pregnancy Hypertension Research Unit, Faculty of Medicine, University of Natal, Congella, South Africa
          Article
          189532 Nephron 1997;75:201–207
          10.1159/000189532
          9041542
          © 1997 S. Karger AG, Basel

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          Page count
          Pages: 7
          Categories
          Original Paper

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