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      Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19

      , M.D., , M.Sc., , M.D., , M.D., , M.D., , M.D., , M.D., , M.D., , M.D., , M.D., , M.D., , M.D., , M.D., , M.D., , M.D., , M.D., , M.D., , B.S., , M.Sc., , Ph.D., , M.D., , M.D., , M.D., , M.D., , M.D., , M.D., , M.D., , M.D., , M.D., , M.D., , M.D., , M.D., , M.D., , M.D., , M.D.

      The New England Journal of Medicine

      Massachusetts Medical Society

      Keyword part (code): 2Keyword part (keyword): Hematology/OncologyKeyword part (code): 2_3Keyword part (keyword): Coagulation , 2, Hematology/Oncology, Keyword part (code): 2_3Keyword part (keyword): Coagulation, 2_3, Coagulation, Keyword part (code): 12Keyword part (keyword): Pulmonary/Critical CareKeyword part (code): 12_1Keyword part (keyword): Pulmonary/Critical Care GeneralKeyword part (code): 12_5Keyword part (keyword): Anticoagulation/Thromboembolism , 12, Pulmonary/Critical Care, Keyword part (code): 12_1Keyword part (keyword): Pulmonary/Critical Care GeneralKeyword part (code): 12_5Keyword part (keyword): Anticoagulation/Thromboembolism , 12_1, Pulmonary/Critical Care General, 12_5, Anticoagulation/Thromboembolism, Keyword part (code): 18Keyword part (keyword): Infectious DiseaseKeyword part (code): 18_6Keyword part (keyword): Viral Infections , 18, Infectious Disease, Keyword part (code): 18_6Keyword part (keyword): Viral Infections, 18_6, Viral Infections

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          Coagulopathy in Critical Illness with Covid-19

          The authors describe a 69-year-old man with Covid-19 diagnosed in January 2020 in Wuhan, China, along with two other critically ill patients with Covid-19 who were also seen in the same intensive care unit. Coagulopathy and antiphospholipid antibodies were seen in all three patients.

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          Most cited references 1

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          Viral infections and antiphospholipid antibodies.

           I W Uthman,  A Gharavi (2002)
          To study the relationship between viral infections and the induction of antiphospholipid (aPL) antibodies. We reviewed the medical literature from 1968 until 2000 using MEDLINE and the key words virus, infection, antiphospholipid, and anticardiolipin. Anticardiolipin antibodies and/or lupus anticoagulant were associated with a number of viral infections, including hepatitis C virus, human immunodeficiency virus, cytomegalovirus, varicella zoster, Epstein-Barr virus, adenovirus, and parvovirus B. In many instances, the presence of these antibodies was associated with thrombosis. The clinical significance of finding aPL antibodies in patients with viral infections remains unknown. In some patients, these antibodies may be transient and disappear within 2 or 3 months. In other susceptible individuals, they may persist and raise the question of whether infections may trigger the development of aPL antibodies in autoimmune diseases. Copyright 2002, Elsevier Science (USA). All rights reserved.
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            Author and article information

            Journal
            N Engl J Med
            N. Engl. J. Med
            nejm
            The New England Journal of Medicine
            Massachusetts Medical Society
            0028-4793
            1533-4406
            08 April 2020
            Affiliations
            Peking Union Medical College Hospital, Beijing, China yongzhelipumch@ 123456126.com shuyangzhang103@ 123456163.com
            Article
            NJ202004083821702
            10.1056/NEJMc2007575
            7161262
            32268022
            Copyright © 2020 Massachusetts Medical Society. All rights reserved.
            Product
            Categories
            Correspondence
            Covid-19 Cases
            Custom metadata
            2020-04-08T17:00:00-04:00
            2020
            04
            08
            17
            00
            00
            -04:00

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