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      MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies

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          Abstract

          MYC oncogene is a transcription factor with a wide array of functions affecting cellular activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to the multi-functionality of MYC, its expression is regulated at multiple levels. Deregulation of this oncogene can give rise to a variety of cancers. In this review, MYC regulation and the mechanisms by which MYC adjusts cellular functions and its implication in hematologic malignancies are summarized. Further, we also discuss potential inhibitors of MYC that could be beneficial for treating hematologic malignancies.

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          Re-epithelialization and immune cell behaviour in an ex vivo human skin model

          Ana Rakita, Nenad Nikolić, Michael Mildner … (2020)
          A large body of literature is available on wound healing in humans. Nonetheless, a standardized ex vivo wound model without disruption of the dermal compartment has not been put forward with compelling justification. Here, we present a novel wound model based on application of negative pressure and its effects for epidermal regeneration and immune cell behaviour. Importantly, the basement membrane remained intact after blister roof removal and keratinocytes were absent in the wounded area. Upon six days of culture, the wound was covered with one to three-cell thick K14+Ki67+ keratinocyte layers, indicating that proliferation and migration were involved in wound closure. After eight to twelve days, a multi-layered epidermis was formed expressing epidermal differentiation markers (K10, filaggrin, DSG-1, CDSN). Investigations about immune cell-specific manners revealed more T cells in the blister roof epidermis compared to normal epidermis. We identified several cell populations in blister roof epidermis and suction blister fluid that are absent in normal epidermis which correlated with their decrease in the dermis, indicating a dermal efflux upon negative pressure. Together, our model recapitulates the main features of epithelial wound regeneration, and can be applied for testing wound healing therapies and investigating underlying mechanisms.
          Article 0 comments Cited 2689 times – based on 0 reviews     Review now
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            Double-slit photoelectron interference in strong-field ionization of the neon dimer

            Maksim Kunitski, Nicolas Eicke, Pia Huber … (2019)
            Wave-particle duality is an inherent peculiarity of the quantum world. The double-slit experiment has been frequently used for understanding different aspects of this fundamental concept. The occurrence of interference rests on the lack of which-way information and on the absence of decoherence mechanisms, which could scramble the wave fronts. Here, we report on the observation of two-center interference in the molecular-frame photoelectron momentum distribution upon ionization of the neon dimer by a strong laser field. Postselection of ions, which are measured in coincidence with electrons, allows choosing the symmetry of the residual ion, leading to observation of both, gerade and ungerade, types of interference.
            Article 0 comments Cited 2445 times – based on 0 reviews     Review now
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              The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia.

              Daniel Arber, Attilio Orazi, Robert P. Hasserjian … (2016)
              The World Health Organization (WHO) classification of tumors of the hematopoietic and lymphoid tissues was last updated in 2008. Since then, there have been numerous advances in the identification of unique biomarkers associated with some myeloid neoplasms and acute leukemias, largely derived from gene expression analysis and next-generation sequencing that can significantly improve the diagnostic criteria as well as the prognostic relevance of entities currently included in the WHO classification and that also suggest new entities that should be added. Therefore, there is a clear need for a revision to the current classification. The revisions to the categories of myeloid neoplasms and acute leukemia will be published in a monograph in 2016 and reflect a consensus of opinion of hematopathologists, hematologists, oncologists, and geneticists. The 2016 edition represents a revision of the prior classification rather than an entirely new classification and attempts to incorporate new clinical, prognostic, morphologic, immunophenotypic, and genetic data that have emerged since the last edition. The major changes in the classification and their rationale are presented here.
              Article 0 comments Cited 2049 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Rouzbeh Chegeni: rchegeni@niu.edu
                Majid Safa:
                ORCID: http://orcid.org/0000-0003-0070-6620
                safa.m@iums.ac.ir
                Journal
                Journal ID (nlm-ta): J Hematol Oncol
                Journal ID (iso-abbrev): J Hematol Oncol
                Title: Journal of Hematology & Oncology
                Publisher: BioMed Central (London )
                ISSN (Electronic): 1756-8722
                Publication date (Electronic): 9 August 2021
                Publication date PMC-release: 9 August 2021
                Publication date Collection: 2021
                Volume: 14
                Electronic Location Identifier: 121
                Affiliations
                [1 ]GRID grid.411746.1, ISNI 0000 0004 4911 7066, Department of Hematology and Blood Banking, Faculty of Allied Medicine, , Iran University of Medical Sciences, ; Tehran, Iran
                [2 ]GRID grid.261128.e, ISNI 0000 0000 9003 8934, Medical Laboratory Sciences Program, College of Health and Human Sciences, , Northern Illinois University, ; DeKalb, IL USA
                [3 ]GRID grid.411746.1, ISNI 0000 0004 4911 7066, Cellular and Molecular Research Center, , Iran University of Medical Sciences, ; Tehran, Iran
                Author information
                http://orcid.org/0000-0003-0070-6620
                Article
                Publisher ID: 1111
                DOI: 10.1186/s13045-021-01111-4
                PMC ID: 8351444
                PubMed ID: 34372899
                SO-VID: 5d6d765c-ebf2-490e-b460-e706fa069a1b
                Copyright © © The Author(s) 2021
                License:

                Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

                History
                Date received : 8 March 2021
                Date accepted : 12 June 2021
                Categories
                Subject: Review
                Custom metadata
                issue-copyright-statement © The Author(s) 2021

                ScienceOpen disciplines: Oncology & Radiotherapy
                Keywords: myc,oncogene,regulation,cell cycle,apoptosis,dna damage response,prognostic importance,therapeutic implications,hematological malignancies
                Data availability:
                ScienceOpen disciplines: Oncology & Radiotherapy
                Keywords: myc, oncogene, regulation, cell cycle, apoptosis, dna damage response, prognostic importance, therapeutic implications, hematological malignancies

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