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      2-aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca2+ entry but an inconsistent inhibitor of InsP3-induced Ca2+ release.

      The FASEB Journal

      metabolism, Animals, Receptors, Cytoplasmic and Nuclear, pharmacology, Oxazoles, Mice, Macrocyclic Compounds, drug effects, Ion Transport, Inositol 1,4,5-Trisphosphate Receptors, antagonists & inhibitors, Inositol 1,4,5-Trisphosphate, Calcium Signaling, Calcium Channels, Calcium Channel Blockers, Calcium, Boron Compounds

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          Abstract

          Since its introduction to Ca2+ signaling in 1997, 2-aminoethoxydiphenyl borate (2-APB) has been used in many studies to probe for the involvement of inositol 1,4,5-trisphosphate receptors in the generation of Ca2+ signals. Due to reports of some nonspecific actions of 2-APB, and the fact that its principal antagonistic effect is on Ca2+ entry rather than Ca2+ release, this compound may not have the utility first suggested. However, 2-APB has thrown up some interesting results, particularly with respect to store-operated Ca2+ entry in nonexcitable cells. These data indicate that although it must be used with caution, 2-APB can be useful in probing certain aspects of Ca2+ signaling.

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          Journal
          10.1096/fj.02-0037rev
          12153982

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