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Immunomodulation by targeted anticancer agents
December 2020
December 2020
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Abstract
<p class="first" id="d751054e111">At odds with conventional chemotherapeutics, targeted
anticancer agents are designed
to inhibit precise molecular alterations that support oncogenesis or tumor progression.
Despite such an elevated degree of molecular specificity, many clinically employed
and experimental targeted anticancer agents also mediate immunostimulatory or immunosuppressive
effects that (at least in some settings) influence therapeutic efficacy. Here, we
discuss the main immunomodulatory effects of targeted anticancer agents and explore
potential avenues to harness them in support of superior clinical efficacy.
</p>