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      Staphylococcal manipulation of host immune responses.

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          Abstract

          Staphylococcus aureus, a bacterial commensal of the human nares and skin, is a frequent cause of soft tissue and bloodstream infections. A hallmark of staphylococcal infections is their frequent recurrence, even when treated with antibiotics and surgical intervention, which demonstrates the bacterium's ability to manipulate innate and adaptive immune responses. In this Review, we highlight how S. aureus virulence factors inhibit complement activation, block and destroy phagocytic cells and modify host B cell and T cell responses, and we discuss how these insights might be useful for the development of novel therapies against infections with antibiotic resistant strains such as methicillin-resistant S. aureus.

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          Author and article information

          Journal
          Nat. Rev. Microbiol.
          Nature reviews. Microbiology
          1740-1534
          1740-1526
          Sep 2015
          : 13
          : 9
          Affiliations
          [1 ] 1] Department of Microbiology, University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA. [2] Regeneron Pharmaceuticals, 755 Old Saw Mill River Road, Tarrytown, New York 10591, USA.
          [2 ] Department of Microbiology, University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA.
          Article
          nrmicro3521 NIHMS731362
          10.1038/nrmicro3521
          26272408

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