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      Turning the promise of multipurpose prevention technologies into a market reality: a commentary

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          Abstract

          The promise of multipurpose prevention technologies (MPTs) for the prevention of HIV and unintended pregnancy are on the horizon. While many are still in clinical development, others are closer to becoming a realistic, accessible option for users, like the dual prevention pill (DPP). Researchers, governments, donors, and implementers will have to collaboratively address systemic challenges to successfully introduce and scale-up MPTs. To ensure the rollout of MPTs is successful, the global community should address user and country-specific needs, coordinate with advocates and policymakers, and set a realistic plan for product introduction and scale-up that considers the needs of both family planning (FP) and HIV programs, while laying the groundwork for future new product introduction. To achieve these aims, global and regional stakeholder coordination should emphasize country-led, person-centered decision-making while addressing: (1) procurement and supply chain barriers; (2) the potential burden on health systems; and (3) the impact on current programs.

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          Most cited references19

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          Declines in Unintended Pregnancy in the United States, 2008-2011.

          The rate of unintended pregnancy in the United States increased slightly between 2001 and 2008 and is higher than that in many other industrialized countries. National trends have not been reported since 2008.
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            Maternal deaths averted by contraceptive use: an analysis of 172 countries.

            Family planning is one of the four pillars of the Safe Motherhood Initiative to reduce maternal death in developing countries. We aimed to estimate the effect of contraceptive use on maternal mortality and the expected reduction in maternal mortality if the unmet need for contraception were met, at country, regional, and world levels. We extracted relevant data from the Maternal Mortality Estimation Inter-Agency Group (MMEIG) database, the UN World Contraceptive Use 2010 database, and the UN World Population Prospects 2010 database, and applied a counterfactual modelling approach (model I), replicating the MMEIG (WHO) maternal mortality estimation method, to estimate maternal deaths averted by contraceptive use in 172 countries. We used a second model (model II) to make the same estimate for 167 countries and to estimate the effect of satisfying unmet need for contraception. We did sensitivity analyses and compared agreement between the models. We estimate, using model I, that 342,203 women died of maternal causes in 2008, but that contraceptive use averted 272,040 (uncertainty interval 127,937-407,134) maternal deaths (44% reduction), so without contraceptive use, the number of maternal deaths would have been 1·8 times higher than the 2008 total. Satisfying unmet need for contraception could prevent another 104,000 maternal deaths per year (29% reduction). Numbers of unwanted pregnancies and unmet contraceptive need are still high in many developing countries. We provide evidence that use of contraception is a substantial and effective primary prevention strategy to reduce maternal mortality in developing countries. Bill and Melinda Gates Foundation. Copyright © 2012 Elsevier Ltd. All rights reserved.
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              Internal construct validity of the Shirom-Melamed Burnout Questionnaire (SMBQ)

              Background Burnout is a mental condition defined as a result of continuous and long-term stress exposure, particularly related to psychosocial factors at work. This paper seeks to examine the psychometric properties of the Shirom-Melamed Burnout Questionnaire (SMBQ) for validation of use in a clinical setting. Methods Data from both a clinical (319) and general population (319) samples of health care and social insurance workers were included in the study. Data were analysed using both classical and modern test theory approaches, including Confirmatory Factor Analysis (CFA) and Rasch analysis. Results Of the 638 people recruited into the study 416 (65%) persons were working full or part time. Data from the SMBQ failed a CFA, and initially failed to satisfy Rasch model expectations. After the removal of 4 of the original items measuring tension, and accommodating local dependency in the data, model expectations were met. As such, the total score from the revised scale is a sufficient statistic for ascertaining burnout and an interval scale transformation is available. The scale as a whole was perfectly targeted to the joint sample. A cut point of 4.4 for severe burnout was chosen at the intersection of the distributions of the clinical and general population. Conclusion A revised 18 item version of the SMBQ satisfies modern measurement standards. Using its cut point it offers the opportunity to identify potential clinical cases of burnout.
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                Author and article information

                Contributors
                Journal
                Front Reprod Health
                Front Reprod Health
                Front. Reprod. Health
                Frontiers in Reproductive Health
                Frontiers Media S.A.
                2673-3153
                2673-3153
                02 November 2023
                2023
                : 5
                : 1181043
                Affiliations
                [ 1 ]Office of HIV/AIDS, United States Agency for International Development , Washington, DC, United States
                [ 2 ]Global Health Training, Advisory, and Support Contract (GHTASC), Credence Management Solutions LLC , Washington, DC, United States
                [ 3 ]Office of Population and Reproductive Health, United States Agency for International Development , Washington, DC, United States
                [ 4 ]Global Health Training, Advisory, and Support Contract (GHTASC), Public Health Institute , Washington, DC, United States
                Author notes

                Edited by: Barbara Friedland, Population Council, United States

                Reviewed by: Bethany Young Holt, CAMI Health, United States

                [* ] Correspondence: Ashley Vij avij@ 123456usaid.gov
                Article
                10.3389/frph.2023.1181043
                10652864
                38023534
                60f871a4-30bb-4992-9076-d8a6125cd22b
                © 2023 Dam, Schueller, Peine, Mason, Dorward and Vij.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 06 March 2023
                : 16 October 2023
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 39, Pages: 0, Words: 0
                Categories
                Reproductive Health
                Perspective
                Custom metadata
                HIV and STIs

                hiv prevention,contraception,multipurpose prevention technologies,mpts,prep (pre-exposure prophylaxis),family planning (fp) prep-fp integration,dual prevention pill,informed choice

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