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The relationship between sex hormones, sex hormone binding globulin and peripheral artery disease in older persons.
M Maggio
1 ,
C Cattabiani ,
F Lauretani ,
A Artoni ,
S Bandinelli ,
G Schiavi ,
A Vignali ,
R Volpi ,
G Ceresini ,
G Lippi ,
R Aloe ,
F De Vita ,
F Giallauria ,
M M McDermott ,
L Ferrucci ,
G P Ceda
Dec 2012
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Abstract
The prevalence of peripheral artery disease (PAD) increases with aging and is higher in persons with metabolic syndrome and diabetes. PAD is associated with adverse outcomes, including frailty and disability. The protective effect of testosterone and sex hormone binding globulin (SHBG) for diabetes in men suggests that the biological activity of sex hormones may affect PAD, especially in older populations.