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      'Entourage' effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors.

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          Abstract

          The endocannabinoid N-arachidonoylethanolamide (anandamide) is co-synthesized with other N-acylethanolamides, namely N-palmitoylethanolamide (PEA) and N-oleoylethanolamide (OEA), which have been shown to potentiate anandamide responses (so-called 'entourage effects') in non-vascular tissues. It remains unclear whether such interactions occur in the circulation.

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          Author and article information

          Journal
          Br J Pharmacol
          British journal of pharmacology
          Springer Science and Business Media LLC
          1476-5381
          0007-1188
          Nov 2008
          : 155
          : 6
          Affiliations
          [1 ] School of Biomedical Sciences, University of Nottingham Medical School, Queen's Medical Centre, Nottingham, UK. vho@sgul.ac.uk
          Article
          bjp2008324
          10.1038/bjp.2008.324
          2597234
          18695637
          65b4f9f3-b105-491b-bdb3-d3185587f591
          History

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