Flow Photochemistry as a Tool in Organic Synthesis

Abstract

Photochemical transformations of molecular building blocks have become an important and widely recognized research field in the past decade. Detailed and deep understanding of novel photochemical catalysts and reaction concepts with visible light as the energy source has enabled a broad application portfolio for synthetic organic chemistry. In parallel, continuous‐flow chemistry and microreaction technology have become the basis for thinking and doing chemistry in a novel fashion with clear focus on improved process control for higher conversion and selectivity. As can be seen by the large number of scientific publications on flow photochemistry in the recent past, both research topics have found each other as exceptionally well‐suited counterparts with high synergy by combining chemistry and technology. This review will give an overview on selected reaction classes, which represent important photochemical transformations in synthetic organic chemistry, and which benefit from mild and defined process conditions by the transfer from batch to continuous‐flow mode.

Abstract

Photon4FlowSynthesis: Continuous‐flow technology and photochemistry have joined forces recently to overcome physical restrictions in the synthesis of complex organic molecules. As result of this fruitful combination, flow photochemistry has become a reliable methodology in the portfolio of modern organic synthesis under mild and defined conditions.