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      Electrochemical sensors based on metal and semiconductor nanoparticles

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      Microchimica Acta

      Springer Nature

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          Most cited references 233

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          In vitro selection of RNA molecules that bind specific ligands.

          Subpopulations of RNA molecules that bind specifically to a variety of organic dyes have been isolated from a population of random sequence RNA molecules. Roughly one in 10(10) random sequence RNA molecules folds in such a way as to create a specific binding site for small ligands.
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            Semiconductor Clusters, Nanocrystals, and Quantum Dots

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              Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase.

              High-affinity nucleic acid ligands for a protein were isolated by a procedure that depends on alternate cycles of ligand selection from pools of variant sequences and amplification of the bound species. Multiple rounds exponentially enrich the population for the highest affinity species that can be clonally isolated and characterized. In particular one eight-base region of an RNA that interacts with the T4 DNA polymerase was chosen and randomized. Two different sequences were selected by this procedure from the calculated pool of 65,536 species. One is the wild-type sequence found in the bacteriophage mRNA; one is varied from wild type at four positions. The binding constants of these two RNA's to T4 DNA polymerase are equivalent. These protocols with minimal modification can yield high-affinity ligands for any protein that binds nucleic acids as part of its function; high-affinity ligands could conceivably be developed for any target molecule.
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                Author and article information

                Journal
                Microchimica Acta
                Microchim Acta
                Springer Nature
                0026-3672
                1436-5073
                April 2009
                January 2009
                : 165
                : 1-2
                : 1-22
                Article
                10.1007/s00604-009-0136-4
                © 2009
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