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      Eclectic Ocular Comorbidities and Systemic Diseases with Eye Involvement: A Review

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          Abstract

          Coexistence of several ocular diseases is more frequent than suspected. In spite of the refractive errors, one or more of the following can be detected simultaneously: glaucoma, cataracts, uveitis, age-related macular degeneration, and dry eyes. In addition, as people age, ocular comorbidities are much more usually seen. Specific diseases are openly acknowledged to affect the eyes and vision, such as diabetes mellitus, hypertension blood pressure, arthritis, hyperthyroidism, neurodegenerative disorders, hematologic malignancies, and/or systemic infections. Recent advances in early diagnosis and therapy of the ophthalmic pathologies have reinforced patient options to prevent visual impairment and blindness. Because of this, it is essential not to overlook sight-threatening conditions such as the ocular comorbidities and/or the eye involvement in the context of systemic disorders. Moreover, the important role of the multidisciplinary cooperation to improve and sustain management of patients affected with eclectic ocular comorbidities and/or systemic disorders with eye repercussion is specifically addressed. This review intends to shed light on these topics to help in making opportune diagnosis and appropriately managing the affected patients.

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          Most cited references74

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          Why Summary Comorbidity Measures Such As the Charlson Comorbidity Index and Elixhauser Score Work.

          Comorbidity adjustment is an important component of health services research and clinical prognosis. When adjusting for comorbidities in statistical models, researchers can include comorbidities individually or through the use of summary measures such as the Charlson Comorbidity Index or Elixhauser score. We examined the conditions under which individual versus summary measures are most appropriate.
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            Is Open Access

            Diagnosing the severity of dry eye: a clear and practical algorithm

            Dry eye disease (DED) is a distressing ocular condition. Due to its multifactorial nature, clinical and biological signs of DED can be inconsistent and sometimes discordant with symptomatology. Consequently, no gold-standard model for determining DED severity exists. This can impact treatment decisions and complicate evaluation of disease progression, particularly within the stringent context of clinical trials. The multinational ODISSEY European Consensus Group is comprised of ophthalmologists who contend with ocular surface disease issues on a daily basis. This group convened to establish a clear and practical algorithm for evaluation and diagnosis of severe DED. Using a consensus-based approach, they assessed 14 commonly used DED severity criteria. The panel agreed that following confirmed DED diagnosis, just two criteria, symptom-based assessment and corneal fluorescein staining were sufficient to diagnose the presence of severe DED in the majority of patients. In the event of discordance between signs and symptoms, further evaluation using additional determinant criteria was recommended. This report presents the ODISSEY European Consensus Group recommended algorithm for DED evaluation, which facilitates diagnosis of severe disease even in the event of discordance between signs and symptoms. It is intended that this algorithm will be useful in a clinical and developmental setting.
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              Abusive head trauma in infants and children.

              Shaken baby syndrome is a term often used by physicians and the public to describe abusive head trauma inflicted on infants and young children. Although the term is well known and has been used for a number of decades, advances in the understanding of the mechanisms and clinical spectrum of injury associated with abusive head trauma compel us to modify our terminology to keep pace with our understanding of pathologic mechanisms. Although shaking an infant has the potential to cause neurologic injury, blunt impact or a combination of shaking and blunt impact cause injury as well. Spinal cord injury and secondary hypoxic ischemic injury can contribute to poor outcomes of victims. The use of broad medical terminology that is inclusive of all mechanisms of injury, including shaking, is required. The American Academy of Pediatrics recommends that pediatricians develop skills in the recognition of signs and symptoms of abusive head injury, including those caused by both shaking and blunt impact, consult with pediatric subspecialists when necessary, and embrace a less mechanistic term, abusive head trauma, when describing an inflicted injury to the head and its contents.
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                Author and article information

                Journal
                Biomed Res Int
                Biomed Res Int
                BMRI
                BioMed Research International
                Hindawi Publishing Corporation
                2314-6133
                2314-6141
                2016
                14 March 2016
                : 2016
                : 6215745
                Affiliations
                1Ophthalmic Research Unit “Santiago Grisolía”, Fundación Investigación Biomédica y Sanitaria (FISABIO), Avenida Gaspar Aguilar 90, 46017 Valencia, Spain
                2Ophthalmology Research Unit, Department of Surgery, Faculty of Medicine and Odontology, University of Valencia, Avenida Blasco Ibáñez 15, 46010 Valencia, Spain
                3Spanish Net of Ophthalmic Pathology (OFTARED), Instituto de Salud Carlos III, C/Sinesio Delgado 4, 28029 Madrid, Spain
                4Ophthalmology Department, University Hospital Reina Sofia, Avenida Intendente Jorge Palacios 1, 30003 Murcia, Spain
                5Retina Division, The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Nelson Building, 600 N. Wolf Street, Baltimore, MD 21287, USA
                6Department of Ophthalmology, University and Polytechnic Hospital La Fe, Avenida Fernando Abril Martorell 106, 46026 Valencia, Spain
                7Ophthalmic Unit, Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, 81 Oxford Street, 00133 Rome, Italy
                Author notes
                *María D. Pinazo-Durán: dolores.pinazo@ 123456uv.es

                Academic Editor: Mitsuru Nakazawa

                Author information
                http://orcid.org/0000-0002-0823-8836
                Article
                10.1155/2016/6215745
                4808667
                27051666
                690a436a-4382-4e73-b0c3-b57701163252
                Copyright © 2016 María D. Pinazo-Durán et al.

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 11 October 2015
                : 1 January 2016
                : 1 February 2016
                Categories
                Review Article

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