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      Renal medullary carcinoma and sickle cell trait: A systematic review.

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          Abstract

          Sickle cell trait (SCT) carries a small risk of renal medullary carcinoma (RMC). We conducted a systematic literature review and reported new four RMC cases (total N = 217). Eighty eight percent had SCT and 8% had sickle cell disease; 50% were children. Males had 2.4× risk than females. Isolated hematuria or in combination with abdominal or flank pain was the presenting sign in 66% cases. Tumor-related mortality was 95%. Four non-metastatic patients were long-term disease-free survivors. Although risk appears to be very low, individuals with SCT should be informed about the low risk of RMC with the hope of early diagnosis. Hematuria should prompt immediate investigation.

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          Author and article information

          Journal
          Pediatr Blood Cancer
          Pediatric blood & cancer
          Wiley-Blackwell
          1545-5017
          1545-5009
          Oct 2015
          : 62
          : 10
          Affiliations
          [1 ] Division of Pediatric Hematology-Oncology, University of Miami, Miami, Florida.
          [2 ] Division of Pediatric Pathology, University of Miami, Miami, Florida.
          [3 ] Department of Public Health Sciences, University of Miami, Miami, Florida.
          [4 ] Division of Pediatric Hematology-Oncology, Children's Hospital of Michigan, Detroit, Michigan.
          Article
          10.1002/pbc.25592
          26053587

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