Gut microbiota regulates neuropathic pain: potential mechanisms and therapeutic strategy

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Abstract

Neuropathic pain (NP) is a sustained and nonreversible condition characterized by long-term devastating physical and psychological damage. Therefore, it is urgent to identify an effective treatment for NP. Unfortunately, the precise pathogenesis of NP has not been elucidated. Currently, the microbiota-gut-brain axis has drawn increasing attention, and the emerging role of gut microbiota is investigated in numerous diseases including NP. Gut microbiota is considered as a pivotal regulator in immune, neural, endocrine, and metabolic signaling pathways, which participates in forming a complex network to affect the development of NP directly or indirectly. In this review, we conclude the current understanding of preclinical and clinical findings regarding the role of gut microbiota in NP and provide a novel therapeutic method for pain relief by medication and dietary interventions.

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Author and article information

Contributors

Gang Chen:

ORCID: http://orcid.org/0000-0003-4262-9491

chengang120@zju.edu.cn

Journal

Journal ID (nlm-ta): J Headache Pain

Journal ID (iso-abbrev): J Headache Pain

Title: The Journal of Headache and Pain

Publisher: Springer Milan (Milan )

ISSN (Print): 1129-2369

ISSN (Electronic): 1129-2377

Publication date (Electronic): 17 August 2020

Publication date PMC-release: 17 August 2020

Publication date Collection: 2020

Volume: 21

Issue: 1

Electronic Location Identifier: 103

Affiliations

GRID grid.13402.34, ISNI 0000 0004 1759 700X, Department of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, , Zhejiang University, ; 3 Qingchun East Road, Zhejiang, 310016 Hangzhou China

Author information

Gang Chen http://orcid.org/0000-0003-4262-9491

Article

Publisher ID: 1170

DOI: 10.1186/s10194-020-01170-x

PMC ID: 7433133

PubMed ID: 32807072

SO-VID: 6a494f8a-aa7f-4aa4-b022-fadb835d9e3c

License:

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