Worldwide dynamic biogeography of zoonotic and anthroponotic dengue

Abstract

Dengue is a viral disease transmitted by mosquitoes. The rapid spread of dengue could lead to a global pandemic, and so the geographical extent of this spread needs to be assessed and predicted. There are also reasons to suggest that transmission of dengue from non-human primates in tropical forest cycles is being underestimated. We investigate the fine-scale geographic changes in transmission risk since the late 20 ^th century, and take into account for the first time the potential role that primate biogeography and sylvatic vectors play in increasing the disease transmission risk. We apply a biogeographic framework to the most recent global dataset of dengue cases. Temporally stratified models describing favorable areas for vector presence and for disease transmission are combined. Our models were validated for predictive capacity, and point to a significant broadening of vector presence in tropical and non-tropical areas globally. We show that dengue transmission is likely to spread to affected areas in China, Papua New Guinea, Australia, USA, Colombia, Venezuela, Madagascar, as well as to cities in Europe and Japan. These models also suggest that dengue transmission is likely to spread to regions where there are presently no or very few reports of occurrence. According to our results, sylvatic dengue cycles account for a small percentage of the global extent of the human case record, but could be increasing in relevance in Asia, Africa, and South America. The spatial distribution of factors favoring transmission risk in different regions of the world allows for distinct management strategies to be prepared.

Author summary

The rate of disease emergence is increasing globally, and many long-existing diseases are extending their distribution ranges. This is the case for dengue, a global pandemic whose mosquito vectors are currently occupying ever-increasing numbers of regions worldwide. We updated the most complete global dataset of dengue cases available, and addressed the fine-scale analysis of the geographic changes experienced in dengue-transmission risk since the late 20 ^th century. Our approach is the first to take into account the potential role of primates and sylvatic vectors in increasing the disease transmission risk in tropical forests. We built models that describe the favorable areas for vector presence and for disease occurrence, and combined them in order to obtain a novel model for predicting transmission risk. We show that dengue transmission is likely to spread to affected areas in Asia, Africa, North and South America, and Oceania, and to regions with presently no or very few cases, including cities in Europe and Japan. The global contribution of sylvatic dengue cycles is small but meaningful. Our methodological approach can differentiate the factors favoring risk in different world regions, thus allowing for management strategies to be prepared specifically for each of these regions.