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      The efficacy of guided growth as an initial strategy for Blount disease treatment

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          Abstract

          Purpose

          The aim of this study was to evaluate the success of guided growth by temporal hemiepiphysiodesis of the lateral proximal tibia as a first line treatment option for Blount disease.

          Methods

          This was a retrospective multicentre study conducted in five centres, covering data on 55 limbs in 45 patients, with an average follow-up of 24.5 months following plate insertion. Preoperative alignment analysis was compared with three measurements taken postoperatively. The normalization of the mechanical medial proximal tibia angle (mMPTA) was defined as the primary outcome measure.

          Results

          Mean age at surgery was 9.5 years. Average preoperative mMPTA was 77°. On average, at 24.5 months post-surgery, mMPTA was 86.33°, while 43/55 limbs (78.18%) have achieved normalization (mMPTA 85° to 90°). Average rate of correction was 1° per month. When grouping the children as infantile (11 limbs), juvenile (12 limbs) and adolescent (32 limbs), operated on before the age of four years, between four and ten years and after the age of ten years, respectively, 63.63%, 66.67%, 87.5% have completed correction of deformity during the follow-up period. Interestingly, the femoral component of the deformity has achieved correction as well in 33/55 limbs (64%).

          Conclusion

          Hemiepiphysiodesis is an effective first line treatment for Blount disease. Overall success rate is good but varies according to child’s age. Adolescent Blount has the best chance of achieving full correction while same treatment is less effective in infantile Blount.

          Level of evidence: IV

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          Most cited references25

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          Guided growth for angular correction: a preliminary series using a tension band plate.

          The classic treatment of pathological angular deformities of the extremities is corrective osteotomy; however, osteotomies require hospitalization, pain management, immobilization, and delayed weight bearing. The associated risks, inconvenience, and cost of osteotomy make hemiepiphysiodesis or guided growth an attractive option. Although stapling has a long and proven track record, reported drawbacks related to implant failure, including migration or breakage of staples, have led some to abandon this technique. This report describes a prospective series of 34 consecutive patients who presented with a total of 65 deformities (femur and/or tibia) due to a variety of pathological conditions and who underwent guided growth using a nonlocking extraperiosteal 2-hole plate and screws. This technique relies upon the tension band principle rather than physeal compression. With follow-up ranging from 14 to 26 months (from implantation) in this series, 32 of 34 patients (63 deformity levels) have corrected to neutral at a mean of 11 months and the hardware has been removed. The observed rate of correction was approximately 30% more rapid than noted with stapling, and there have been no permanent growth arrests. Four patients with bilateral idiopathic genu valgum experienced rebound deformity and have since undergone repeat guided growth using the same technique. Only 2 patients with adolescent Blount disease have experienced insufficient correction; each may need a corrective osteotomy of the tibia. Having prevented 63 (97%) of 65 osteotomies in this series of patients, it is evident that guided growth holds promise for postponing if not preventing more invasive surgery.These patients will be observed up to maturity to support my conclusion that the concept of osteotomy as a first resort and criterion standard has become outdated.
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            Mechanical axis deviation of the lower limbs. Preoperative planning of uniapical angular deformities of the tibia or femur.

            Angular deformities of the tibia or femur in the frontal plane lead to mechanical axis deviation of the lower limb and malorientation of the joints above and below the level of deformity. Accurate correction of the malalignment and of the joint orientation is important for function and to prevent joint degeneration. An accurate yet simple method to determine the apex of deformity and the type of correction required is based on the joint reference lines of the hip, knee, and ankle, and the individual mechanical axis lines of each bone segment. If the osteotomy is performed at the level of the apex of the deformity, then the only correction needed is angulation. If the osteotomy is performed at a level proximal or distal to the apex, then translation in addition to angulation is necessary to accurately correct the deformity.
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              Failure of Orthofix eight-Plate for the treatment of Blount disease.

              Hemiepiphysiodesis is a well-established treatment option for angular deformities of the knee. Recently, our institution began using the eight-Plate tension band device by Orthofix (McKinney, Tex) as an alternative to staples. However, several patients have returned with broken screws necessitating revision surgery. Charts and radiographs of all patients who were treated with the eight-Plate (Orthofix) at our institution were reviewed. The diagnosis, age, amount of angular deformity, weight, and body mass index were analyzed with respect to eventual implant failure. Implant failure occurred in 8 (26%) of 31 proximal tibia constructs. All 8 failures occurred in patients with Blount disease and involved breakage of the tibial metaphyseal screw. The mean time to failure was 13.6 months. Eight hardware failures in 18 Blount disease extremities represent a failure rate of 44%. No implant failures occurred in the remaining diagnoses. Neither age nor degree of deformity correlated with implant failure. The failure group was significantly heavier than the nonfailure group, and the patients with Blount disease were found to be heavier than the other patients. However, no significant difference in weight was found within the Blount group regarding implant failure. In all patients whose plates did not fail, rate of correction was equal to or better than previously reported hemiepiphysiodesis studies. The eight-Plate (Orthofix) is a reasonable option for hemiepiphysiodesis but has an unacceptable failure rate in Blount disease (44%). There were no instances of failure in patients with other diagnoses. In Blount disease, stronger implants should be considered. Future implant designs should include stronger screws to decrease implant failure complications.
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                Author and article information

                Journal
                J Child Orthop
                J Child Orthop
                jco
                Journal of Children's Orthopaedics
                The British Editorial Society of Bone & Joint Surgery (London )
                1863-2521
                1863-2548
                1 August 2020
                : 14
                : 4
                : 312-317
                Affiliations
                [1 ] org-divisionThe Department of Pediatric Orthopaedics, Dana Children’s Hospital, Tel-Aviv Sourasky Medical Center , Tel-Aviv, Israel
                [2 ] org-divisionSackler Faculty of Medicine, Tel Aviv University , Tel Aviv, Israel
                [3 ] org-divisionKlinik und Poliklinik für Allgemeine Orthopädie und Tumororthopädie, Universitätsklinikum Münster , Münster, Germany
                [4 ] org-divisionInternational Center for Limb Lengthening, Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore , Baltimore, USA
                [5 ] org-divisionCohen Children’s Hospital, Zucker School of Medicine , New York, USA
                [6 ] org-divisionOrthopedic Hospital Speising Vienna , Vienna, Austria
                [7 ] org-divisionSickkids Hospital Toronto , Toronto, Canada
                Author notes
                Correspondence should be sent to Barry Danino, org-divisionDana’s Children Hospital , Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv 64239, Israel. E-mail: barrydanino@ 123456hotmail.com
                Article
                jco-14-312
                10.1302/1863-2548.14.200070
                7453169
                32874365
                6c8bfd58-25e2-4b89-8852-00cb42eafbf7
                Copyright © 2020, The author(s)

                Open Access This article is distributed under the terms of the Creative Commons Attribution-Non Commercial 4.0 International (CC BY-NC 4.0) licence ( https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed.

                History
                : 02 May 2020
                : 02 July 2020
                Categories
                Original Clinical Article
                childrens-orthopaedics, Children’s Orthopaedics

                Orthopedics
                blount,hemiepiphysiodesis,guided growth,limb deformity
                Orthopedics
                blount, hemiepiphysiodesis, guided growth, limb deformity

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