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      A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells.

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          Abstract

          The molecular mechanisms directing the development of 'natural' CD4+CD25+Foxp3+ regulatory T cells (T(reg) cells) in the thymus are not thoroughly understood. We show here that conditional deletion of transforming growth factor-beta receptor I (TbetaRI) in T cells blocked the appearance of CD4+CD25+Foxp3+ thymocytes at postnatal days 3-5. Paradoxically, however, beginning 1 week after birth, the same TbetaRI-mutant mice showed accelerated expansion of thymic CD4+CD25+Foxp3+ populations. This rapid recovery of Foxp3+ thymocytes was attributable mainly to overproduction of and heightened responsiveness to interleukin 2, as genetic ablation of interleukin 2 in TbetaRI-mutant mice resulted in a complete absence of CD4+CD25+Foxp3+ cells from the thymus and periphery. Thus, transforming growth factor-beta signaling is critical to the thymic development of natural CD4+CD25+Foxp3+ T(reg) cells.

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          Author and article information

          Journal
          Nat Immunol
          Nature immunology
          Springer Science and Business Media LLC
          1529-2916
          1529-2908
          Jun 2008
          : 9
          : 6
          Affiliations
          [1 ] Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA.
          Article
          ni.1607
          10.1038/ni.1607
          18438410
          6e8401df-b310-417b-912b-94b5ff2b2f3e
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