+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Die Feinstruktur der Venenwand bei Varikose


      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          The normal ultrastructure of a large cutaneous vein of the (hind) leg is described in an introductory chapter. This mentions, inter alia, the demonstration of acid mucopolysaccharides periodically attached to collagen fibrils, the immature character of most elastic fibres in the tunica intima and tunica media, and the mature aspect of elastic tissue in the tunica adventitia. Both varicose and non-varicose venous specimens of 60 patients with varicosis were examined. Two thirds of the varices were classified as belonging to the type which we have proposed to call C-type (C for collagen) with normally developed, mature elastic tissue in the tunica adventitia, but with foci of abnormal collagen fibrils in the vicinity of smooth muscle cells. The abnormal fibrils show swelling and helical splitting, resembling the findings of Peracchia and Vassallo (1966) in thromboangiitis obliterans. Collagen fibrils with periodical cloud-like attachments are also found. The relation of the latter to a possible coarsening of the periodically attached structures with acid groups remains unclear. Less than one third of the varices are described as the type which we have proposed to call E-type (E for elastic tissue) with an immature aspect of most elastic tissue of the tunica adventitia and only sparse abnormal collagen fibrils. The E-type cases are generally advanced varices, often with some sclerosis. Five mixed cases were found, showing characteristics both of the C-type and the E-type. Especially in patients with E-type varices, abnormal collagen fibrils were found in the non-varicose specimens, too. Such fibrils could not be demonstrated in the connective tissue of inguinal skin of varicosis patients. In non-varicose venae saphenae magnae of five coronary patients abnormal collagen fibrils were abundantly found. In a control case they occurred sporadically and in the vena tibialis of cattle not at all. In varicose and non-varicose specimens of the great saphenous vein of varicosis patients the vasa vasorum may show multiple laminae densae in the endothelial basement membrane. The discussion includes remarks on a possible pathophysiological enzymic influence of the smooth muscle cells on the surrounding connective tissue.

          Related collections

          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          18 September 2008
          : 8
          : 6
          : 318-346
          Zwillenberg Tietz Laboratorium, Bern, und Forschungsinstitut für Kardioangiologie, Fribourg
          157905 Angiologica 1971;8:318–346
          © 1971 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 29

          General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
          Veins,Varicosis,Ultrastructure,Connective tissue,Collagen,Elastic tissue,Acid mucopolysaccharides,Basement membrane


          Comment on this article