Fast water-exchange Gd3+-(DO3A-like) complex functionalized with aza-15-crown-5 showing prolonged residence lifetime in vivo.

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Abstract

A bis-hydrated Gd3+ complex based on tris acetic acid-1,4,7,10-tetraazacyclododecane (DO3A) that was functionalized with aza-15-crown-5 demonstrated a nearly optimal water-exchanging rate (k(ex) = 3.1 x 10(7) s(-1)) and low acute cytotoxicity. Efficient magnetic resonance signal intensity enhancements and prolonged residence lifetime induced by this small molecular complex in vivo were demonstrated even with one-fifth of the standard dosage used in the clinic.

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Journal

Journal ID (iso-abbrev): Bioconjug. Chem.

Title: Bioconjugate chemistry

Publisher: American Chemical Society (ACS)

ISSN: 1043-1802

ISSN (Print): 1043-1802

Publication date (Electronic): May 18 2006

Volume: 17

Issue: 3

Affiliations

[1 ] Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, PR China.

Article

DOI: 10.1021/bc060003m

PubMed ID: 16704192

SO-VID: 6f6fc549-b02c-47e7-937d-929873de2129

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