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      A nanocomposite consisting of an amorphous seed and a molecularly imprinted covalent organic framework shell for extraction and HPLC determination of nonsteroidal anti-inflammatory drugs.

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          Abstract

          A novel nanocomposite consisting of an amorphous seed and a molecularly imprinted covalent organic framework shell was prepared via a heterogeneous nucleation and growth method. By using ibuprofen as the dummy template, a molecularly imprinted covalent organic framework (MICOF) with a large surface area was prepared from 1,3,5-triformylbenzene and 4,4'-diaminobiphenyl. It was placed on the surface of monodisperse amorphous seeds. Owing to strong π-interaction, the MICOF@SiO2 nanocomposite displays fast binding kinetics, large adsorption capacities and selectivity for nonsteroidal anti-inflammatory drugs (NSAIDs). Following desorption from the MICOF@SiO2 with methanol containing 1% ammonium hydroxide, the NSAIDs ketoprofen, ibuprofen, diclofenac, indomethacin, flurbiprofen and naproxen were quantified by HPLC with UV detection. Under optimized conditions, the method exhibits good linearity within the range of 0.002-1.0 μg mL-1, low limits of detection (0.38-2.92 μg L-1), and acceptable repeatability. The recoveries of NSAIDs at three spiking levels range from 77 to 112%, and the RSDs are <9.4%. The method was successfully applied to the analysis of NSAIDs in spiked environmental water samples. Graphical abstract A molecular imprinted covalent organic framework nanocomposite (MICOF@SiO2) was prepared by heterogeneous nucleation and growth method. It was explored as a sorbent for the solid phase extraction of nonsteroidal anti-inflammatory drugs before determination by HPLC with UV detection.

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          Author and article information

          Journal
          Mikrochim Acta
          Mikrochimica acta
          Springer Science and Business Media LLC
          1436-5073
          0026-3672
          January 09 2019
          : 186
          : 2
          Affiliations
          [1 ] Department of Chemistry, Zhejiang University, Xixi Campus, Hangzhou, 310028, China.
          [2 ] Department of Chemistry, Zhejiang University, Xixi Campus, Hangzhou, 310028, China. zhuyan@zju.edu.cn.
          [3 ] Department of Medicine, Zhejiang Academy of Traditional Chinese Medicine, Hangzhou, 310007, China.
          [4 ] Hangzhou Vocational & Technical College, Hangzhou, 310028, China.
          Article
          10.1007/s00604-018-3187-6
          10.1007/s00604-018-3187-6
          30627789
          71e30a3d-e7d7-4560-a8d0-f1c105039917
          History

          1,3,5-triformylbenzene,4,4′-diaminobiphenyl,Amorphous seed,Heterogeneous nucleation and growth method,π-Interaction

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